The association of hypertriglyceridemia with cardiovascular events and pancreatitis: A systematic review and meta-analysis

M. Hassan Murad, Ahmad Hazem, Fernando Coto-Yglesias, Svitlana Dzyubak, Shabnum Gupta, Irina Bancos, Melanie A. Lane, Patricia J. Erwin, Lars Berglund, Tarig Elraiyah, Victor M. Montori

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.Methods: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.Results: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.Conclusions: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.

Original languageEnglish (US)
Article number2
JournalBMC Endocrine Disorders
Volume12
DOIs
StatePublished - Mar 31 2012

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Hypertriglyceridemia
Pancreatitis
Meta-Analysis
Odds Ratio
Confidence Intervals
Fasting
Bibliographic Databases
Social Adjustment
Observational Studies
Myocardial Infarction
Mortality

Keywords

  • Cardiovascular disease
  • Hypertriglyceridemia
  • Pancreatitis
  • Systematic reviews and meta-analysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

The association of hypertriglyceridemia with cardiovascular events and pancreatitis : A systematic review and meta-analysis. / Murad, M. Hassan; Hazem, Ahmad; Coto-Yglesias, Fernando; Dzyubak, Svitlana; Gupta, Shabnum; Bancos, Irina; Lane, Melanie A.; Erwin, Patricia J.; Berglund, Lars; Elraiyah, Tarig; Montori, Victor M.

In: BMC Endocrine Disorders, Vol. 12, 2, 31.03.2012.

Research output: Contribution to journalArticle

Murad, MH, Hazem, A, Coto-Yglesias, F, Dzyubak, S, Gupta, S, Bancos, I, Lane, MA, Erwin, PJ, Berglund, L, Elraiyah, T & Montori, VM 2012, 'The association of hypertriglyceridemia with cardiovascular events and pancreatitis: A systematic review and meta-analysis', BMC Endocrine Disorders, vol. 12, 2. https://doi.org/10.1186/1472-6823-12-2
Murad, M. Hassan ; Hazem, Ahmad ; Coto-Yglesias, Fernando ; Dzyubak, Svitlana ; Gupta, Shabnum ; Bancos, Irina ; Lane, Melanie A. ; Erwin, Patricia J. ; Berglund, Lars ; Elraiyah, Tarig ; Montori, Victor M. / The association of hypertriglyceridemia with cardiovascular events and pancreatitis : A systematic review and meta-analysis. In: BMC Endocrine Disorders. 2012 ; Vol. 12.
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AU - Dzyubak, Svitlana

AU - Gupta, Shabnum

AU - Bancos, Irina

AU - Lane, Melanie A.

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AU - Berglund, Lars

AU - Elraiyah, Tarig

AU - Montori, Victor M.

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N2 - Background: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.Methods: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.Results: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.Conclusions: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.

AB - Background: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.Methods: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.Results: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.Conclusions: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.

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