The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans

Yanlei Du; Min Yang; Hung Wen Yeh; Yu-Jui Yvonne Wan

doi:10.1016/j.psychres.2010.02.021

The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans

Yanlei Du, Min Yang, Hung Wen Yeh, Yu-Jui Yvonne Wan

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.

Original language	English (US)
Pages (from-to)	358-360
Number of pages	3
Journal	Psychiatry Research
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.psychres.2010.02.021
State	Published - May 2010
Externally published	Yes

Keywords

Alcoholism
Dopamine receptor D4
Mexican American
Polymorphism
Reward

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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abstract = "In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.",

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T1 - The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans

AU - Du, Yanlei

AU - Yang, Min

AU - Yeh, Hung Wen

AU - Wan, Yu-Jui Yvonne

PY - 2010/5

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AB - In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.

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KW - Dopamine receptor D4

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KW - Polymorphism

KW - Reward

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