The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans

Yanlei Du, Min Yang, Hung Wen Yeh, Yu-Jui Yvonne Wan

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.

Original languageEnglish (US)
Pages (from-to)358-360
Number of pages3
JournalPsychiatry Research
Volume177
Issue number3
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Alcoholism
  • Dopamine receptor D4
  • Mexican American
  • Polymorphism
  • Reward

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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