Abstract
In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 358-360 |
| Number of pages | 3 |
| Journal | Psychiatry Research |
| Volume | 177 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2010 |
| Externally published | Yes |
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Keywords
- Alcoholism
- Dopamine receptor D4
- Mexican American
- Polymorphism
- Reward
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans. / Du, Yanlei; Yang, Min; Yeh, Hung Wen; Wan, Yu-Jui Yvonne.
In: Psychiatry Research, Vol. 177, No. 3, 05.2010, p. 358-360.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans
AU - Du, Yanlei
AU - Yang, Min
AU - Yeh, Hung Wen
AU - Wan, Yu-Jui Yvonne
PY - 2010/5
Y1 - 2010/5
N2 - In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.
AB - In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24. h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans.
KW - Alcoholism
KW - Dopamine receptor D4
KW - Mexican American
KW - Polymorphism
KW - Reward
UR - http://www.scopus.com/inward/record.url?scp=77952669969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952669969&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2010.02.021
DO - 10.1016/j.psychres.2010.02.021
M3 - Article
C2 - 20359751
AN - SCOPUS:77952669969
VL - 177
SP - 358
EP - 360
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 3
ER -