The association of complete laryngotracheoesophageal cleft with left lung agenesis: Pathophysiological clues provided by an experiment of nature

Michael J. Noorily, Diana L Farmer, Alan W. Flake

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The authors present a patient with complete laryngotracheoesophageal cleft and concurrent left lung agenesis and microgastria. Prenatal ultrasound scan showed polyhydramnios and a hypertrophic right lung. The authors propose that the combination of right lung hypertrophy, polyhydramnios, and microgastria in the absence of a competent laryngeal mechanism may suggest that the preferential path for swallowed amniotic fluid was into the lung, rather than the normal route through the stomach. This case illustrates the prenatal findings suggestive of complete laryngotracheoesophageal cleft and lung agenesis, and suggests a potential causal relationship between shunting of swallowed amniotic fluid into the bronchial tree and prenatal lung hypertrophy and microgastria.

Original languageEnglish (US)
Pages (from-to)1546-1549
Number of pages4
JournalJournal of Pediatric Surgery
Volume33
Issue number10
DOIs
StatePublished - Oct 1998
Externally publishedYes

Keywords

  • Gastroesophageal reflux
  • Laryngeal sphincter
  • Laryngotracheoesophageal cleft
  • Lung agenesis
  • Microgastria

ASJC Scopus subject areas

  • Surgery

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