The association between p,p″-DDE levels and left ventricular mass is mainly mediated by obesity

Michele La Merrill, P. M. Lind, S. Salihovic, B. van Bavel, L. Lind

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background and objectives The pesticide metabolite p,p′-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p′-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p′-DDE with LV mass. Methods p,p′-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques. Results We found that p,p′-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p′-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%). Conclusion The obesogenic effect of p,p′-DDE is a major determinant responsible for the association of p,p′-DDE with LV mass.

Original languageEnglish (US)
Pages (from-to)541-546
Number of pages6
JournalEnvironmental Research
Volume160
DOIs
StatePublished - Jan 1 2018

Keywords

  • Glucose
  • Hypertension
  • Left ventricular hypertrophy
  • Obesity
  • P,p′-DDE

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

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