The association between p,p″-DDE levels and left ventricular mass is mainly mediated by obesity

Michele La Merrill, P. M. Lind, S. Salihovic, B. van Bavel, L. Lind

Research output: Contribution to journalArticle

Abstract

Background and objectives The pesticide metabolite p,p′-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p′-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p′-DDE with LV mass. Methods p,p′-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques. Results We found that p,p′-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p′-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%). Conclusion The obesogenic effect of p,p′-DDE is a major determinant responsible for the association of p,p′-DDE with LV mass.

Original languageEnglish (US)
Pages (from-to)541-546
Number of pages6
JournalEnvironmental Research
Volume160
DOIs
StatePublished - Jan 1 2018

Fingerprint

Dichlorodiphenyl Dichloroethylene
obesity
DDE
Obesity
hypertension
body mass
glucose
fasting
Body Mass Index
Left Ventricular Hypertrophy
Hypertension
risk factor
Glucose
Fasting
Echocardiography
Blood pressure
Adiposity
Metabolites
Pesticides
metabolite

Keywords

  • Glucose
  • Hypertension
  • Left ventricular hypertrophy
  • Obesity
  • P,p′-DDE

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

The association between p,p″-DDE levels and left ventricular mass is mainly mediated by obesity. / La Merrill, Michele; Lind, P. M.; Salihovic, S.; van Bavel, B.; Lind, L.

In: Environmental Research, Vol. 160, 01.01.2018, p. 541-546.

Research output: Contribution to journalArticle

La Merrill, Michele ; Lind, P. M. ; Salihovic, S. ; van Bavel, B. ; Lind, L. / The association between p,p″-DDE levels and left ventricular mass is mainly mediated by obesity. In: Environmental Research. 2018 ; Vol. 160. pp. 541-546.
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