The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The cardiovascular health study

Bruce M. Psaty, Melissa Anderson, Richard A. Kronmal, Russell P. Tracy, Trevor Orchard, Linda P. Fried, Thomas Lumley, John A Robbins, Greg Burke, Anne B. Newman, Curt D. Furberg

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

OBJECTIVES: To assess the association between lipid levels and cardiovascular events in older adults. DESIGN: A prospective population-based study. SETTING: Four field centers in U.S. communities. PARTICIPANTS: A total of 5,201 adults aged 65 and older living in U.S. communities, plus a recruitment of 687 African Americans 3 years later. MEASUREMENTS: Fasting lipid measures included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, and triglycerides. RESULTS: At baseline, 1,954 men and 2,931 women were at risk for an incident myocardial infarction (MI) or stroke. During an average 7.5-year follow-up, 436 subjects had a coronary event, 332 had an ischemic stroke, 104 a hemorrhagic stroke, and 1,096 died. After adjustment, lipid measures were not major predictors of the outcomes of MI, ischemic stroke, hemorrhagic stroke, and total mortality. For total cholesterol and LDL-C, the associations with MI and ischemic stroke were only marginally significant. HDL-C was inversely associated with MI risk (hazard ratio = 0.85 per standard deviation of 15.7mg/dL, 95% confidence interval = 0.76-0.96). For the outcome of ischemic stroke, high levels of HDL-C were associated with a decreased risk in men but not women. Lipid measures were generally only weakly associated with the risks of hemorrhagic stroke or total mortality. CONCLUSION: In this population-based study of older adults, most lipid measures were weakly associated with cardiovascular events. The association between low HDL-C and increased MI risk was nonetheless strong and consistent.

Original languageEnglish (US)
Pages (from-to)1639-1647
Number of pages9
JournalJournal of the American Geriatrics Society
Volume52
Issue number10
DOIs
StatePublished - Oct 2004

Keywords

  • Cholesterol
  • Lipids
  • Myocardial infarction
  • Older adults
  • Stroke
  • Total mortality

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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    Psaty, B. M., Anderson, M., Kronmal, R. A., Tracy, R. P., Orchard, T., Fried, L. P., Lumley, T., Robbins, J. A., Burke, G., Newman, A. B., & Furberg, C. D. (2004). The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The cardiovascular health study. Journal of the American Geriatrics Society, 52(10), 1639-1647. https://doi.org/10.1111/j.1532-5415.2004.52455.x