The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women

Michele La Merrill, Luisa Torres-Sánchez, Rubén Ruiz-Ramos, Lizbeth López-Carrillo, Mariano E. Cebrián, Jia Chen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objective. Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women. Methods.A semi-quantitative dietary questionnaire was administered to 195 women during their first trimester in Morelos, Mexico. Two functional polymorphisms of the key folate-metabolizing gene, i.e. MTHFR 677 C>T and 1298 A>C, as well as global DNA methylation were assessed in peripheral blood drawn during the interview. Results. Independent of maternal age and caloric intake, vitamin B 6 deficiency was associated with 1.8 fold increased risk of hypomethylation in women carrying the MTHFR 677 T allele. Conclusions. There exists a subpopulation that is more susceptible to B vitamin deficiencies.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Keywords

  • Epigenetics
  • Micronutrient deficiency
  • MTHFR 677
  • One carbon metabolism
  • Vitamin B6

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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