The association between chlamydia trachomatis and ectopic pregnancy: A matched-pair, case-control study

Joan M. Chow, M. Lynn Yonekura, Gary A. Richwald, Sander Greenland, Richard L Sweet, Julius Schachter

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Abstract

We performed a case-control study of the association of past exposure to Chlamydia trachomatis and ectopic pregnancy with 306 case patients with an ectopic pregnancy and 266 pregnant patients who served as controls. The geometric mean antichlamydial antibody titer among cases was 75 ± 10.2 vs 13 ± 11.0 among controls. The matched-pair odds ratio for ectopic pregnancy and IgG titer of 1:64 or greater to C trachomatis was 3.0 (95% confidence interval, 2.1 to 4.4). Adjusting for age at first intercourse, total lifetime partners, douching, history of infertility, and parity yielded a relative risk of 2.4 (95% confidence interval, 1.5 to 3.3). Current douching remained an independent risk factor after controlling for chlamydial exposure, with an adjusted relative risk of 2.1 (95% confidence interval, 1.3 to 3.5). The population attributable fraction for chlamydial infection was 0.47 and that for douching was 0.45. The results stress the need for control of C trachomatis infections and for further study of specific douching behaviors as risk factors for ectopic pregnancy.

Original languageEnglish (US)
Pages (from-to)3164-3167
Number of pages4
JournalJournal of the American Medical Association
Volume263
Issue number23
StatePublished - 1990

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Ectopic Pregnancy
Chlamydia trachomatis
Therapeutic Irrigation
Case-Control Studies
Confidence Intervals
Coitus
Infection
Parity
Infertility
Immunoglobulin G
Odds Ratio
Antibodies
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chow, J. M., Lynn Yonekura, M., Richwald, G. A., Greenland, S., Sweet, R. L., & Schachter, J. (1990). The association between chlamydia trachomatis and ectopic pregnancy: A matched-pair, case-control study. Journal of the American Medical Association, 263(23), 3164-3167.

The association between chlamydia trachomatis and ectopic pregnancy : A matched-pair, case-control study. / Chow, Joan M.; Lynn Yonekura, M.; Richwald, Gary A.; Greenland, Sander; Sweet, Richard L; Schachter, Julius.

In: Journal of the American Medical Association, Vol. 263, No. 23, 1990, p. 3164-3167.

Research output: Contribution to journalArticle

Chow, JM, Lynn Yonekura, M, Richwald, GA, Greenland, S, Sweet, RL & Schachter, J 1990, 'The association between chlamydia trachomatis and ectopic pregnancy: A matched-pair, case-control study', Journal of the American Medical Association, vol. 263, no. 23, pp. 3164-3167.
Chow, Joan M. ; Lynn Yonekura, M. ; Richwald, Gary A. ; Greenland, Sander ; Sweet, Richard L ; Schachter, Julius. / The association between chlamydia trachomatis and ectopic pregnancy : A matched-pair, case-control study. In: Journal of the American Medical Association. 1990 ; Vol. 263, No. 23. pp. 3164-3167.
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