The association between autism and fragile X syndrome

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The fragile X syndrome in males presents with a number of autistic features, including poor eye contact, hand-flapping, hand-biting, attentional deficits, tactile defensiveness, perseverative speech, and difficulties with social interactions, although a pervasive lack of relatedness is usually not present. There exists, therefore, a significant degree of overlap between autism and fragile X syndrome. Approximately 7% of autistic males havethe fragile X syndrome, and preliminary work suggests a similar prevalence in autistic females. We hypothesize frontal lobe dysfunction in fragile X syndrome interfering with sensory associations, integration, and inhibition which leads to autistic features. Preliminary neuropsychological studies in fragile X females document frontal lobe deficits.

Original languageEnglish (US)
Pages (from-to)218-227
Number of pages10
JournalBrain Dysfunction
Volume3
Issue number5-6
StatePublished - 1990
Externally publishedYes

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Fragile X Syndrome
Autistic Disorder
Frontal Lobe
Hand
Touch
Interpersonal Relations

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The association between autism and fragile X syndrome. / Hagerman, Randi J.

In: Brain Dysfunction, Vol. 3, No. 5-6, 1990, p. 218-227.

Research output: Contribution to journalArticle

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