Abstract
The fragile X syndrome in males presents with a number of autistic features, including poor eye contact, hand-flapping, hand-biting, attentional deficits, tactile defensiveness, perseverative speech, and difficulties with social interactions, although a pervasive lack of relatedness is usually not present. There exists, therefore, a significant degree of overlap between autism and fragile X syndrome. Approximately 7% of autistic males havethe fragile X syndrome, and preliminary work suggests a similar prevalence in autistic females. We hypothesize frontal lobe dysfunction in fragile X syndrome interfering with sensory associations, integration, and inhibition which leads to autistic features. Preliminary neuropsychological studies in fragile X females document frontal lobe deficits.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-227 |
| Number of pages | 10 |
| Journal | Brain Dysfunction |
| Volume | 3 |
| Issue number | 5-6 |
| State | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
The association between autism and fragile X syndrome. / Hagerman, Randi J.
In: Brain Dysfunction, Vol. 3, No. 5-6, 1990, p. 218-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association between autism and fragile X syndrome
AU - Hagerman, Randi J
PY - 1990
Y1 - 1990
N2 - The fragile X syndrome in males presents with a number of autistic features, including poor eye contact, hand-flapping, hand-biting, attentional deficits, tactile defensiveness, perseverative speech, and difficulties with social interactions, although a pervasive lack of relatedness is usually not present. There exists, therefore, a significant degree of overlap between autism and fragile X syndrome. Approximately 7% of autistic males havethe fragile X syndrome, and preliminary work suggests a similar prevalence in autistic females. We hypothesize frontal lobe dysfunction in fragile X syndrome interfering with sensory associations, integration, and inhibition which leads to autistic features. Preliminary neuropsychological studies in fragile X females document frontal lobe deficits.
AB - The fragile X syndrome in males presents with a number of autistic features, including poor eye contact, hand-flapping, hand-biting, attentional deficits, tactile defensiveness, perseverative speech, and difficulties with social interactions, although a pervasive lack of relatedness is usually not present. There exists, therefore, a significant degree of overlap between autism and fragile X syndrome. Approximately 7% of autistic males havethe fragile X syndrome, and preliminary work suggests a similar prevalence in autistic females. We hypothesize frontal lobe dysfunction in fragile X syndrome interfering with sensory associations, integration, and inhibition which leads to autistic features. Preliminary neuropsychological studies in fragile X females document frontal lobe deficits.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025530095&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0025530095
VL - 3
SP - 218
EP - 227
JO - Brain Dysfunction
JF - Brain Dysfunction
SN - 0259-1278
IS - 5-6
ER -