The ART and science of sperm mitophagy

Won Hee Song, Young Joo Yi, Miriam Sutovsky, Stuart A Meyers, Peter Sutovsky

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Abstract

This article discusses the historical perspective and the new findings of autophagy and ubiquitin-proteasome system cooperation during the post-fertilization sperm mitophagy, a process that eliminates potentially damaged paternal mitochondrial DNA from an early embryo. New insight into the mechanism that promotes clonal, maternal inheritance of mitochondrial genes may be helpful for managing mitochondrial disease and infertility in humans, as well as reproductive performance and production traits in agriculturally important domestic animals.

Original languageEnglish (US)
Pages (from-to)2510-2511
Number of pages2
JournalAutophagy
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Mitochondrial Degradation
Mitochondrial Diseases
Mitochondrial Genes
Domestic Animals
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Mitochondrial DNA
Fertilization
Infertility
Spermatozoa
Embryonic Structures
Maternal Inheritance

Keywords

  • assisted reproductive therapy
  • autophagy
  • mitochondria
  • mitophagy
  • mtDNA
  • SQSTM1
  • ubiquitin-proteasome system
  • VCP

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Song, W. H., Yi, Y. J., Sutovsky, M., Meyers, S. A., & Sutovsky, P. (2016). The ART and science of sperm mitophagy. Autophagy, 12(12), 2510-2511. https://doi.org/10.1080/15548627.2016.1239004

The ART and science of sperm mitophagy. / Song, Won Hee; Yi, Young Joo; Sutovsky, Miriam; Meyers, Stuart A; Sutovsky, Peter.

In: Autophagy, Vol. 12, No. 12, 01.12.2016, p. 2510-2511.

Research output: Contribution to journalComment/debate

Song, WH, Yi, YJ, Sutovsky, M, Meyers, SA & Sutovsky, P 2016, 'The ART and science of sperm mitophagy', Autophagy, vol. 12, no. 12, pp. 2510-2511. https://doi.org/10.1080/15548627.2016.1239004
Song WH, Yi YJ, Sutovsky M, Meyers SA, Sutovsky P. The ART and science of sperm mitophagy. Autophagy. 2016 Dec 1;12(12):2510-2511. https://doi.org/10.1080/15548627.2016.1239004
Song, Won Hee ; Yi, Young Joo ; Sutovsky, Miriam ; Meyers, Stuart A ; Sutovsky, Peter. / The ART and science of sperm mitophagy. In: Autophagy. 2016 ; Vol. 12, No. 12. pp. 2510-2511.
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