The ART and science of sperm mitophagy

Won Hee Song; Young Joo Yi; Miriam Sutovsky; Stuart A Meyers; Peter Sutovsky

doi:10.1080/15548627.2016.1239004

The ART and science of sperm mitophagy

Won Hee Song, Young Joo Yi, Miriam Sutovsky, Stuart A Meyers, Peter Sutovsky

Anatomy, Physiology and Cell Biology

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

This article discusses the historical perspective and the new findings of autophagy and ubiquitin-proteasome system cooperation during the post-fertilization sperm mitophagy, a process that eliminates potentially damaged paternal mitochondrial DNA from an early embryo. New insight into the mechanism that promotes clonal, maternal inheritance of mitochondrial genes may be helpful for managing mitochondrial disease and infertility in humans, as well as reproductive performance and production traits in agriculturally important domestic animals.

Original language	English (US)
Pages (from-to)	2510-2511
Number of pages	2
Journal	Autophagy
Volume	12
Issue number	12
DOIs	https://doi.org/10.1080/15548627.2016.1239004
State	Published - Dec 1 2016

Keywords

assisted reproductive therapy
autophagy
mitochondria
mitophagy
mtDNA
SQSTM1
ubiquitin-proteasome system
VCP

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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AU - Yi, Young Joo

AU - Sutovsky, Miriam

AU - Meyers, Stuart A

AU - Sutovsky, Peter

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AB - This article discusses the historical perspective and the new findings of autophagy and ubiquitin-proteasome system cooperation during the post-fertilization sperm mitophagy, a process that eliminates potentially damaged paternal mitochondrial DNA from an early embryo. New insight into the mechanism that promotes clonal, maternal inheritance of mitochondrial genes may be helpful for managing mitochondrial disease and infertility in humans, as well as reproductive performance and production traits in agriculturally important domestic animals.

KW - assisted reproductive therapy

KW - autophagy

KW - mitochondria

KW - mitophagy

KW - mtDNA

KW - SQSTM1

KW - ubiquitin-proteasome system

KW - VCP

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The ART and science of sperm mitophagy

Abstract

Keywords

ASJC Scopus subject areas

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