The ART and science of sperm mitophagy

Won Hee Song, Young Joo Yi, Miriam Sutovsky, Stuart A Meyers, Peter Sutovsky

Research output: Contribution to journalComment/debate

6 Scopus citations

Abstract

This article discusses the historical perspective and the new findings of autophagy and ubiquitin-proteasome system cooperation during the post-fertilization sperm mitophagy, a process that eliminates potentially damaged paternal mitochondrial DNA from an early embryo. New insight into the mechanism that promotes clonal, maternal inheritance of mitochondrial genes may be helpful for managing mitochondrial disease and infertility in humans, as well as reproductive performance and production traits in agriculturally important domestic animals.

Original languageEnglish (US)
Pages (from-to)2510-2511
Number of pages2
JournalAutophagy
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • assisted reproductive therapy
  • autophagy
  • mitochondria
  • mitophagy
  • mtDNA
  • SQSTM1
  • ubiquitin-proteasome system
  • VCP

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Song, W. H., Yi, Y. J., Sutovsky, M., Meyers, S. A., & Sutovsky, P. (2016). The ART and science of sperm mitophagy. Autophagy, 12(12), 2510-2511. https://doi.org/10.1080/15548627.2016.1239004