The applications of atomic force microscopy to vision science

Julie A. Last, Paul Russell, Paul F. Nealey, Christopher J Murphy

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The atomic force microscope (AFM) is widely used in materials science and has found many applications in biological sciences but has been limited in use in vision science.The AFM can be used to image the topography of soft biological materials in their native environments.It can also be used to probe the mechanical properties of cells and extracellular matrices, including their intrinsic elastic modulus and receptor-ligand interactions.In this review, the operation of the AFM is described along with a review of how it has been thus far used in vision science.It is hoped that this review will serve to stimulate vision scientists to consider incorporating AFM as part of their research toolkit.

Original languageEnglish (US)
Pages (from-to)6083-6094
Number of pages12
JournalInvestigative Ophthalmology and Visual Science
Issue number12
StatePublished - Dec 2010

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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