The applications of atomic force microscopy to vision science

Julie A. Last, Paul Russell, Paul F. Nealey, Christopher J Murphy

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The atomic force microscope (AFM) is widely used in materials science and has found many applications in biological sciences but has been limited in use in vision science.The AFM can be used to image the topography of soft biological materials in their native environments.It can also be used to probe the mechanical properties of cells and extracellular matrices, including their intrinsic elastic modulus and receptor-ligand interactions.In this review, the operation of the AFM is described along with a review of how it has been thus far used in vision science.It is hoped that this review will serve to stimulate vision scientists to consider incorporating AFM as part of their research toolkit.

Original languageEnglish (US)
Pages (from-to)6083-6094
Number of pages12
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number12
DOIs
StatePublished - Dec 2010

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Atomic Force Microscopy
Biological Science Disciplines
Elastic Modulus
Extracellular Matrix
Ligands
Research

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The applications of atomic force microscopy to vision science. / Last, Julie A.; Russell, Paul; Nealey, Paul F.; Murphy, Christopher J.

In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 12, 12.2010, p. 6083-6094.

Research output: Contribution to journalArticle

Last, Julie A. ; Russell, Paul ; Nealey, Paul F. ; Murphy, Christopher J. / The applications of atomic force microscopy to vision science. In: Investigative Ophthalmology and Visual Science. 2010 ; Vol. 51, No. 12. pp. 6083-6094.
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