The application of electrochemotherapy in three dogs with inoperable cancers

Seung Chul Yeom, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticlepeer-review

Abstract

Factors such as location, volume, and the type of neoplasm complicate achieving tumor control. Electrochemotherapy (ECT) is a supplementary treatment for inoperable neoplasms in veterinary patients. Three dogs were diagnosed with a tumor. Two were squamous cell carcinoma (SCC), and the other was liposarcoma, each with a single tumor with the size range of 1 to 5 cm. The tumor locations were the cervical, oral, and abdominal cavity. ECT was selected as a treatment. Bleomycin was injected intratumorally at the dose of 0.5 to 1.0 mg/cm3. Five minutes after the injection, electric pulses applied in a sequence of eight pulses lasting 100 µsec each, were delivered in 1,000 V/cm. An evaluation was performed after 1 week, and the next session was administered 2 weeks later. In a patient with oral SCC, the tumor was in partial remission after two sessions of ECT. Another patient with SCC on her neck was showed complete remission after 2 weeks of ECT administration. A third patient showed stable disease for 8 weeks. Complications were mild and transient and included skin necrosis, edema, local pain, and gait disturbance. ECT is a valid adjuvant, especially for inoperable, cutaneous, or accessible intra-abdominal tumors.

Original languageEnglish (US)
Article numbere7
JournalKorean Journal of Veterinary Research
Volume61
Issue number1
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • Antineoplastic protocols
  • Bleomycin
  • Electrochemotherapy
  • Neoplasms

ASJC Scopus subject areas

  • veterinary(all)

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