The apparent in vivo neuromuscular effects of the δ-endotoxin of Bacillus thuringiensis var. israelensis in mice and insects of four orders

Peter Y K Cheung, Richard M. Roe, Bruce D. Hammock, Charles L. Judson, Mary Ann Montague

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15 Scopus citations


Alkaline-dissolved crystal δ-endotoxin from Bacillus thuringiensis var. israelensis (serovar H 14) was injected into mice and seven species of insects representing the orders Lepidoptera, Orthoptera, Coleoptera, Hemiptera, and Diptera. High in vivo toxicity, at 1 to 5 ppm (μg toxin/g body wet wt), was observed with mice and some insects, including some that are not sensitive to the toxin when administered orally. Neuromuscular effects were observed when the toxin was injected directly into the body cavity of the test animals. Biochemical studies suggested that different protein fragments within the crystal δ-endotoxin may be responsible for the majority of the mosquito larvacidal activity and the neurotoxic symptoms observed in larvae of Trichoplusia ni.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalPesticide Biochemistry and Physiology
Issue number1
StatePublished - 1985


ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Biochemistry
  • Physiology

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