The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period

Robert S. Wilson, Julie A. Schneider, Lisa L. Barnes, Laurel A Beckett, Neelum T. Aggarwal, Elizabeth J. Cochran, Elizabeth Berry-Kravis, Julie Bach, Jacob H. Fox, Denis A. Evans, David A. Bennett

Research output: Contribution to journalArticle

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Abstract

Context: Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) ε4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. Objective: To examine the association of ε4 with decline in different cognitive systems. Design: Longitudinal cohort study. Setting: More than 40 groups of Catholic clergy from across the United States. Participants: Older Catholic clergy members without clinical evidence of dementia at baseline underwent annual clinical evaluations for up to 6 years. Of 624 persons eligible for follow-up, 611 (98%) participated, of whom 161 (26%) had at least 1 ε4 allele. They completed an average of 5.5 evaluations (range, 2-7). Main Outcome Measures: Incident AD and annual rates of change in episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. Results: The presence of ε4 was associated with risk of developing AD on follow-up (relative risk, 1.92; 95% confidence interval, 1.27-2.89). In a series of random effects models, ε4 was associated with impaired baseline function in episodic memory and visuospatial ability and with more rapid decline in all domains. The effect of ε4 on annual decline in episodic memory (>3-fold increase) was significantly stronger than its effect on decline in other cognitive systems (P<.01), and at baseline, its effect on episodic memory was marginally stronger than its effect on other cognitive domains (P=.06). Conclusion: The results suggest that the APOE ε4 allele influences risk of AD by a relatively selective effect on episodic memory.

Original languageEnglish (US)
Pages (from-to)1154-1160
Number of pages7
JournalArchives of Neurology
Volume59
Issue number7
DOIs
StatePublished - 2002
Externally publishedYes

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Apolipoprotein E4
Episodic Memory
Alleles
Alzheimer Disease
Clergy
Aptitude
Allele
Cognitive Systems
Short-Term Memory
Semantics
Cognition
Longitudinal Studies
Dementia
Cohort Studies
Outcome Assessment (Health Care)
Alzheimer's Disease
Confidence Intervals

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wilson, R. S., Schneider, J. A., Barnes, L. L., Beckett, L. A., Aggarwal, N. T., Cochran, E. J., ... Bennett, D. A. (2002). The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period. Archives of Neurology, 59(7), 1154-1160. https://doi.org/10.1001/archneur.59.7.1154

The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period. / Wilson, Robert S.; Schneider, Julie A.; Barnes, Lisa L.; Beckett, Laurel A; Aggarwal, Neelum T.; Cochran, Elizabeth J.; Berry-Kravis, Elizabeth; Bach, Julie; Fox, Jacob H.; Evans, Denis A.; Bennett, David A.

In: Archives of Neurology, Vol. 59, No. 7, 2002, p. 1154-1160.

Research output: Contribution to journalArticle

Wilson, RS, Schneider, JA, Barnes, LL, Beckett, LA, Aggarwal, NT, Cochran, EJ, Berry-Kravis, E, Bach, J, Fox, JH, Evans, DA & Bennett, DA 2002, 'The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period', Archives of Neurology, vol. 59, no. 7, pp. 1154-1160. https://doi.org/10.1001/archneur.59.7.1154
Wilson, Robert S. ; Schneider, Julie A. ; Barnes, Lisa L. ; Beckett, Laurel A ; Aggarwal, Neelum T. ; Cochran, Elizabeth J. ; Berry-Kravis, Elizabeth ; Bach, Julie ; Fox, Jacob H. ; Evans, Denis A. ; Bennett, David A. / The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period. In: Archives of Neurology. 2002 ; Vol. 59, No. 7. pp. 1154-1160.
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abstract = "Context: Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) ε4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. Objective: To examine the association of ε4 with decline in different cognitive systems. Design: Longitudinal cohort study. Setting: More than 40 groups of Catholic clergy from across the United States. Participants: Older Catholic clergy members without clinical evidence of dementia at baseline underwent annual clinical evaluations for up to 6 years. Of 624 persons eligible for follow-up, 611 (98{\%}) participated, of whom 161 (26{\%}) had at least 1 ε4 allele. They completed an average of 5.5 evaluations (range, 2-7). Main Outcome Measures: Incident AD and annual rates of change in episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. Results: The presence of ε4 was associated with risk of developing AD on follow-up (relative risk, 1.92; 95{\%} confidence interval, 1.27-2.89). In a series of random effects models, ε4 was associated with impaired baseline function in episodic memory and visuospatial ability and with more rapid decline in all domains. The effect of ε4 on annual decline in episodic memory (>3-fold increase) was significantly stronger than its effect on decline in other cognitive systems (P<.01), and at baseline, its effect on episodic memory was marginally stronger than its effect on other cognitive domains (P=.06). Conclusion: The results suggest that the APOE ε4 allele influences risk of AD by a relatively selective effect on episodic memory.",
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T1 - The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period

AU - Wilson, Robert S.

AU - Schneider, Julie A.

AU - Barnes, Lisa L.

AU - Beckett, Laurel A

AU - Aggarwal, Neelum T.

AU - Cochran, Elizabeth J.

AU - Berry-Kravis, Elizabeth

AU - Bach, Julie

AU - Fox, Jacob H.

AU - Evans, Denis A.

AU - Bennett, David A.

PY - 2002

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N2 - Context: Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) ε4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. Objective: To examine the association of ε4 with decline in different cognitive systems. Design: Longitudinal cohort study. Setting: More than 40 groups of Catholic clergy from across the United States. Participants: Older Catholic clergy members without clinical evidence of dementia at baseline underwent annual clinical evaluations for up to 6 years. Of 624 persons eligible for follow-up, 611 (98%) participated, of whom 161 (26%) had at least 1 ε4 allele. They completed an average of 5.5 evaluations (range, 2-7). Main Outcome Measures: Incident AD and annual rates of change in episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. Results: The presence of ε4 was associated with risk of developing AD on follow-up (relative risk, 1.92; 95% confidence interval, 1.27-2.89). In a series of random effects models, ε4 was associated with impaired baseline function in episodic memory and visuospatial ability and with more rapid decline in all domains. The effect of ε4 on annual decline in episodic memory (>3-fold increase) was significantly stronger than its effect on decline in other cognitive systems (P<.01), and at baseline, its effect on episodic memory was marginally stronger than its effect on other cognitive domains (P=.06). Conclusion: The results suggest that the APOE ε4 allele influences risk of AD by a relatively selective effect on episodic memory.

AB - Context: Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) ε4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. Objective: To examine the association of ε4 with decline in different cognitive systems. Design: Longitudinal cohort study. Setting: More than 40 groups of Catholic clergy from across the United States. Participants: Older Catholic clergy members without clinical evidence of dementia at baseline underwent annual clinical evaluations for up to 6 years. Of 624 persons eligible for follow-up, 611 (98%) participated, of whom 161 (26%) had at least 1 ε4 allele. They completed an average of 5.5 evaluations (range, 2-7). Main Outcome Measures: Incident AD and annual rates of change in episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. Results: The presence of ε4 was associated with risk of developing AD on follow-up (relative risk, 1.92; 95% confidence interval, 1.27-2.89). In a series of random effects models, ε4 was associated with impaired baseline function in episodic memory and visuospatial ability and with more rapid decline in all domains. The effect of ε4 on annual decline in episodic memory (>3-fold increase) was significantly stronger than its effect on decline in other cognitive systems (P<.01), and at baseline, its effect on episodic memory was marginally stronger than its effect on other cognitive domains (P=.06). Conclusion: The results suggest that the APOE ε4 allele influences risk of AD by a relatively selective effect on episodic memory.

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