The antioxidant butylated hydroxytoluene protects against atherosclerosis

I. Bjorkhem, A. Henriksson-Freyschuss, O. Breuer, U. Diczfalusy, Lars Berglund, P. Henriksson

Research output: Contribution to journalArticle

278 Citations (Scopus)

Abstract

Rabbits fed a 1% cholesterol diet with or without the antioxidant butylated hydroxytoluene (BHT) developed typical atherosclerotic lesions. The addition of BHT gave higher levels of total cholesterol (+40%), triglycerides (+250%), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) in plasma. Despite the lower plasma lipid levels, the degree of atherosclerosis of the aortic surface was considerably higher in rabbits fed cholesterol than in the group treated with cholesterol and BHT. The mean atherosclerotic involvement was 18.6 ± 4.4% in the former group and 5.9 ± 1.7% in the latter group (p = 0.02). In all animals, there was a high correlation between the area of the arterial lesion and cholesterol content (r = 0.96). Serum levels of cholesterol autooxidation products (7-ketocholesterol and cholesterol 5α,6α-epoxide) were lower in the group of rabbits treated with BHT (p < 0.005). Serum levels of vitamin E were slightly higher in the BHT group. There was no significant difference in the clearance of β-VLDL between the two treatment groups after using either β-VLDL from cholesterol-fed animals or β-VLDL from BHT-fed animals. The results are in accord with the contention that oxidative modification of lipoproteins is important for the development of atherosclerosis and that antioxidants may have a protective effect. At present, however, other explanations cannot be completely excluded, for example, effects of antioxidants on immunologic factors or monocyte adhesion.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalArteriosclerosis and Thrombosis
Volume11
Issue number1
StatePublished - 1991
Externally publishedYes

Fingerprint

Butylated Hydroxytoluene
Atherosclerosis
Antioxidants
Cholesterol
VLDL Lipoproteins
Rabbits
VLDL Cholesterol
Immunologic Factors
Hypercholesterolemia
Serum
Vitamin E
Lipoproteins
Monocytes
Diet
Lipids

Keywords

  • antioxidants
  • atherosclerosis
  • butylated hydroxytoluene
  • cholesterol-fed rabbits

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bjorkhem, I., Henriksson-Freyschuss, A., Breuer, O., Diczfalusy, U., Berglund, L., & Henriksson, P. (1991). The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arteriosclerosis and Thrombosis, 11(1), 15-22.

The antioxidant butylated hydroxytoluene protects against atherosclerosis. / Bjorkhem, I.; Henriksson-Freyschuss, A.; Breuer, O.; Diczfalusy, U.; Berglund, Lars; Henriksson, P.

In: Arteriosclerosis and Thrombosis, Vol. 11, No. 1, 1991, p. 15-22.

Research output: Contribution to journalArticle

Bjorkhem, I, Henriksson-Freyschuss, A, Breuer, O, Diczfalusy, U, Berglund, L & Henriksson, P 1991, 'The antioxidant butylated hydroxytoluene protects against atherosclerosis', Arteriosclerosis and Thrombosis, vol. 11, no. 1, pp. 15-22.
Bjorkhem I, Henriksson-Freyschuss A, Breuer O, Diczfalusy U, Berglund L, Henriksson P. The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arteriosclerosis and Thrombosis. 1991;11(1):15-22.
Bjorkhem, I. ; Henriksson-Freyschuss, A. ; Breuer, O. ; Diczfalusy, U. ; Berglund, Lars ; Henriksson, P. / The antioxidant butylated hydroxytoluene protects against atherosclerosis. In: Arteriosclerosis and Thrombosis. 1991 ; Vol. 11, No. 1. pp. 15-22.
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