The antagonism of bombesin in the CNS by substance P analogues

Anthony T. Yachnis; Jacqueline Crawley; Robert T. Jensen; Margaret M. McGrane; Terry W. Woody

doi:10.1016/0024-3205(84)90477-6

The antagonism of bombesin in the CNS by substance P analogues

Anthony T. Yachnis, Jacqueline Crawley, Robert T. Jensen, Margaret M. McGrane, Terry W. Woody

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.

Original language	English (US)
Pages (from-to)	1963-1969
Number of pages	7
Journal	Life Sciences
Volume	35
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(84)90477-6
State	Published - Nov 5 1984
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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10.1016/0024-3205(84)90477-6

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AU - Crawley, Jacqueline

AU - Jensen, Robert T.

AU - McGrane, Margaret M.

AU - Woody, Terry W.

PY - 1984/11/5

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AB - The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.

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JO - Life Sciences

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The antagonism of bombesin in the CNS by substance P analogues

Abstract

ASJC Scopus subject areas

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