The antagonism of bombesin in the CNS by substance P analogues

Anthony T. Yachnis, Jacqueline Crawley, Robert T. Jensen, Margaret M. McGrane, Terry W. Woody

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.

Original languageEnglish (US)
Pages (from-to)1963-1969
Number of pages7
JournalLife Sciences
Volume35
Issue number19
DOIs
StatePublished - Nov 5 1984
Externally publishedYes

Fingerprint

Bombesin
Substance P
Hypothermia
Neurokinin-1 Receptors
Induced Hypothermia
Grooming
Aptitude
Biological Assay
Assays
Peptides

ASJC Scopus subject areas

  • Pharmacology

Cite this

Yachnis, A. T., Crawley, J., Jensen, R. T., McGrane, M. M., & Woody, T. W. (1984). The antagonism of bombesin in the CNS by substance P analogues. Life Sciences, 35(19), 1963-1969. https://doi.org/10.1016/0024-3205(84)90477-6

The antagonism of bombesin in the CNS by substance P analogues. / Yachnis, Anthony T.; Crawley, Jacqueline; Jensen, Robert T.; McGrane, Margaret M.; Woody, Terry W.

In: Life Sciences, Vol. 35, No. 19, 05.11.1984, p. 1963-1969.

Research output: Contribution to journalArticle

Yachnis, AT, Crawley, J, Jensen, RT, McGrane, MM & Woody, TW 1984, 'The antagonism of bombesin in the CNS by substance P analogues', Life Sciences, vol. 35, no. 19, pp. 1963-1969. https://doi.org/10.1016/0024-3205(84)90477-6
Yachnis, Anthony T. ; Crawley, Jacqueline ; Jensen, Robert T. ; McGrane, Margaret M. ; Woody, Terry W. / The antagonism of bombesin in the CNS by substance P analogues. In: Life Sciences. 1984 ; Vol. 35, No. 19. pp. 1963-1969.
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