Abstract
The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1963-1969 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 35 |
| Issue number | 19 |
| DOIs | |
| State | Published - Nov 5 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
The antagonism of bombesin in the CNS by substance P analogues. / Yachnis, Anthony T.; Crawley, Jacqueline; Jensen, Robert T.; McGrane, Margaret M.; Woody, Terry W.
In: Life Sciences, Vol. 35, No. 19, 05.11.1984, p. 1963-1969.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The antagonism of bombesin in the CNS by substance P analogues
AU - Yachnis, Anthony T.
AU - Crawley, Jacqueline
AU - Jensen, Robert T.
AU - McGrane, Margaret M.
AU - Woody, Terry W.
PY - 1984/11/5
Y1 - 1984/11/5
N2 - The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
AB - The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
UR - http://www.scopus.com/inward/record.url?scp=0021159221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021159221&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(84)90477-6
DO - 10.1016/0024-3205(84)90477-6
M3 - Article
C2 - 6208451
AN - SCOPUS:0021159221
VL - 35
SP - 1963
EP - 1969
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 19
ER -