Abstract
The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1963-1969 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 35 |
| Issue number | 19 |
| DOIs | |
| State | Published - Nov 5 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
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Cite this
Yachnis, A. T., Crawley, J., Jensen, R. T., McGrane, M. M., & Woody, T. W. (1984). The antagonism of bombesin in the CNS by substance P analogues. Life Sciences, 35(19), 1963-1969. https://doi.org/10.1016/0024-3205(84)90477-6