Abstract
The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
Original language | English (US) |
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Pages (from-to) | 1963-1969 |
Number of pages | 7 |
Journal | Life Sciences |
Volume | 35 |
Issue number | 19 |
DOIs | |
State | Published - Nov 5 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology