The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding

Laurel A Beckett, Michael C. Donohue, Cathy Wang, Paul Aisen, Danielle J Harvey, Naomi Saito

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a multisite study designed to characterize the trajectories of biomarkers across the aging process. We present ADNI Biostatistics Core analyses that integrate data over the length, breadth, and depth of ADNI. Methods Relative progression of key imaging, fluid, and clinical measures was assessed. Individuals with subjective memory complaints (SMC) and early mild cognitive impairment (eMCI) were compared with normal controls (NC), MCI, and individuals with Alzheimer's disease. Amyloid imaging and magnetic resonance imaging (MRI) summaries were assessed as predictors of disease progression. Results Relative progression of markers supports parts of the amyloid cascade hypothesis, although evidence of earlier occurrence of cognitive change exists. SMC are similar to NC, whereas eMCI fall between the cognitively normal and MCI groups. Amyloid leads to faster conversion and increased cognitive impairment. Discussion Analyses support features of the amyloid hypothesis, but also illustrate the considerable heterogeneity in the aging process.

Original languageEnglish (US)
Pages (from-to)823-831
Number of pages9
JournalAlzheimer's and Dementia
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Alzheimer's disease
  • Amyloid cascade hypothesis
  • Subjective memory complaints

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

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