The Alzheimer's Disease Centers' Uniform Data Set (UDS)

The neuropsychologic test battery

Sandra Weintraub, David Salmon, Nathaniel Mercaldo, Steven Ferris, Neill R. Graff-Radford, Helena Chui, Jeffrey Cummings, Charles DeCarli, Norman L. Foster, Douglas Galasko, Elaine Peskind, Woodrow Dietrich, Duane L. Beekly, Walter A. Kukull, John C. Morris

Research output: Contribution to journalArticle

338 Citations (Scopus)

Abstract

The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered "clinically cognitively normal" based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. Regression models investigating the impact of age, education, and sex on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: (1) determining the psychometric properties of the battery; (2) establishing normative data, including norms for different ethnic minority groups; and (3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with Alzheimer disease and other forms of dementia.

Original languageEnglish (US)
Pages (from-to)91-101
Number of pages11
JournalAlzheimer Disease and Associated Disorders
Volume23
Issue number2
DOIs
StatePublished - Apr 2009

Fingerprint

Neuropsychological Tests
Alzheimer Disease
Dementia
National Institute on Aging (U.S.)
Independent Living
Minority Groups
Sex Education
Episodic Memory
Executive Function
Ethnic Groups
Psychometrics
Longitudinal Studies
Volunteers
Language
Datasets
Cognitive Aging

Keywords

  • 80 and over
  • Aged
  • Alzheimer disease/diagnosis
  • Cognition
  • Data collection/method
  • Dementia
  • Neuropsychologic Tests/standards

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology

Cite this

Weintraub, S., Salmon, D., Mercaldo, N., Ferris, S., Graff-Radford, N. R., Chui, H., ... Morris, J. C. (2009). The Alzheimer's Disease Centers' Uniform Data Set (UDS): The neuropsychologic test battery. Alzheimer Disease and Associated Disorders, 23(2), 91-101. https://doi.org/10.1097/WAD.0b013e318191c7dd

The Alzheimer's Disease Centers' Uniform Data Set (UDS) : The neuropsychologic test battery. / Weintraub, Sandra; Salmon, David; Mercaldo, Nathaniel; Ferris, Steven; Graff-Radford, Neill R.; Chui, Helena; Cummings, Jeffrey; DeCarli, Charles; Foster, Norman L.; Galasko, Douglas; Peskind, Elaine; Dietrich, Woodrow; Beekly, Duane L.; Kukull, Walter A.; Morris, John C.

In: Alzheimer Disease and Associated Disorders, Vol. 23, No. 2, 04.2009, p. 91-101.

Research output: Contribution to journalArticle

Weintraub, S, Salmon, D, Mercaldo, N, Ferris, S, Graff-Radford, NR, Chui, H, Cummings, J, DeCarli, C, Foster, NL, Galasko, D, Peskind, E, Dietrich, W, Beekly, DL, Kukull, WA & Morris, JC 2009, 'The Alzheimer's Disease Centers' Uniform Data Set (UDS): The neuropsychologic test battery', Alzheimer Disease and Associated Disorders, vol. 23, no. 2, pp. 91-101. https://doi.org/10.1097/WAD.0b013e318191c7dd
Weintraub, Sandra ; Salmon, David ; Mercaldo, Nathaniel ; Ferris, Steven ; Graff-Radford, Neill R. ; Chui, Helena ; Cummings, Jeffrey ; DeCarli, Charles ; Foster, Norman L. ; Galasko, Douglas ; Peskind, Elaine ; Dietrich, Woodrow ; Beekly, Duane L. ; Kukull, Walter A. ; Morris, John C. / The Alzheimer's Disease Centers' Uniform Data Set (UDS) : The neuropsychologic test battery. In: Alzheimer Disease and Associated Disorders. 2009 ; Vol. 23, No. 2. pp. 91-101.
@article{7f5369135ce24f9da106cc31acabefa1,
title = "The Alzheimer's Disease Centers' Uniform Data Set (UDS): The neuropsychologic test battery",
abstract = "The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered {"}clinically cognitively normal{"} based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. Regression models investigating the impact of age, education, and sex on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: (1) determining the psychometric properties of the battery; (2) establishing normative data, including norms for different ethnic minority groups; and (3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with Alzheimer disease and other forms of dementia.",
keywords = "80 and over, Aged, Alzheimer disease/diagnosis, Cognition, Data collection/method, Dementia, Neuropsychologic Tests/standards",
author = "Sandra Weintraub and David Salmon and Nathaniel Mercaldo and Steven Ferris and Graff-Radford, {Neill R.} and Helena Chui and Jeffrey Cummings and Charles DeCarli and Foster, {Norman L.} and Douglas Galasko and Elaine Peskind and Woodrow Dietrich and Beekly, {Duane L.} and Kukull, {Walter A.} and Morris, {John C.}",
year = "2009",
month = "4",
doi = "10.1097/WAD.0b013e318191c7dd",
language = "English (US)",
volume = "23",
pages = "91--101",
journal = "Alzheimer Disease and Associated Disorders",
issn = "0893-0341",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - The Alzheimer's Disease Centers' Uniform Data Set (UDS)

T2 - The neuropsychologic test battery

AU - Weintraub, Sandra

AU - Salmon, David

AU - Mercaldo, Nathaniel

AU - Ferris, Steven

AU - Graff-Radford, Neill R.

AU - Chui, Helena

AU - Cummings, Jeffrey

AU - DeCarli, Charles

AU - Foster, Norman L.

AU - Galasko, Douglas

AU - Peskind, Elaine

AU - Dietrich, Woodrow

AU - Beekly, Duane L.

AU - Kukull, Walter A.

AU - Morris, John C.

PY - 2009/4

Y1 - 2009/4

N2 - The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered "clinically cognitively normal" based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. Regression models investigating the impact of age, education, and sex on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: (1) determining the psychometric properties of the battery; (2) establishing normative data, including norms for different ethnic minority groups; and (3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with Alzheimer disease and other forms of dementia.

AB - The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered "clinically cognitively normal" based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. Regression models investigating the impact of age, education, and sex on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: (1) determining the psychometric properties of the battery; (2) establishing normative data, including norms for different ethnic minority groups; and (3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with Alzheimer disease and other forms of dementia.

KW - 80 and over

KW - Aged

KW - Alzheimer disease/diagnosis

KW - Cognition

KW - Data collection/method

KW - Dementia

KW - Neuropsychologic Tests/standards

UR - http://www.scopus.com/inward/record.url?scp=67651068689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651068689&partnerID=8YFLogxK

U2 - 10.1097/WAD.0b013e318191c7dd

DO - 10.1097/WAD.0b013e318191c7dd

M3 - Article

VL - 23

SP - 91

EP - 101

JO - Alzheimer Disease and Associated Disorders

JF - Alzheimer Disease and Associated Disorders

SN - 0893-0341

IS - 2

ER -