The ageing cortical synapse

Hallmarks and implications for cognitive decline

John Morrison, Mark G. Baxter

Research output: Contribution to journalReview article

316 Citations (Scopus)

Abstract

Normal ageing is associated with impairments in cognitive function, including memory. These impairments are linked, not to a loss of neurons in the forebrain, but to specific and relatively subtle synaptic alterations in the hippocampus and prefrontal cortex. Here, we review studies that have shed light on the cellular and synaptic changes observed in these brain structures during ageing that can be directly related to cognitive decline in young and aged animals. We also discuss the influence of the hormonal status on these age-related alterations and recent progress in the development of therapeutic strategies to limit the impact of ageing on memory and cognition in humans.

Original languageEnglish (US)
Pages (from-to)240-250
Number of pages11
JournalNature Reviews Neuroscience
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Fingerprint

Synapses
Cognition
Prosencephalon
Prefrontal Cortex
Hippocampus
Neurons
Brain
Cognitive Dysfunction
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The ageing cortical synapse : Hallmarks and implications for cognitive decline. / Morrison, John; Baxter, Mark G.

In: Nature Reviews Neuroscience, Vol. 13, No. 4, 01.04.2012, p. 240-250.

Research output: Contribution to journalReview article

@article{7859ddd10ce04a0997e4d754e5d97dd3,
title = "The ageing cortical synapse: Hallmarks and implications for cognitive decline",
abstract = "Normal ageing is associated with impairments in cognitive function, including memory. These impairments are linked, not to a loss of neurons in the forebrain, but to specific and relatively subtle synaptic alterations in the hippocampus and prefrontal cortex. Here, we review studies that have shed light on the cellular and synaptic changes observed in these brain structures during ageing that can be directly related to cognitive decline in young and aged animals. We also discuss the influence of the hormonal status on these age-related alterations and recent progress in the development of therapeutic strategies to limit the impact of ageing on memory and cognition in humans.",
author = "John Morrison and Baxter, {Mark G.}",
year = "2012",
month = "4",
day = "1",
doi = "10.1038/nrn3200",
language = "English (US)",
volume = "13",
pages = "240--250",
journal = "Nature reviews. Neuroscience",
issn = "1471-003X",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - The ageing cortical synapse

T2 - Hallmarks and implications for cognitive decline

AU - Morrison, John

AU - Baxter, Mark G.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Normal ageing is associated with impairments in cognitive function, including memory. These impairments are linked, not to a loss of neurons in the forebrain, but to specific and relatively subtle synaptic alterations in the hippocampus and prefrontal cortex. Here, we review studies that have shed light on the cellular and synaptic changes observed in these brain structures during ageing that can be directly related to cognitive decline in young and aged animals. We also discuss the influence of the hormonal status on these age-related alterations and recent progress in the development of therapeutic strategies to limit the impact of ageing on memory and cognition in humans.

AB - Normal ageing is associated with impairments in cognitive function, including memory. These impairments are linked, not to a loss of neurons in the forebrain, but to specific and relatively subtle synaptic alterations in the hippocampus and prefrontal cortex. Here, we review studies that have shed light on the cellular and synaptic changes observed in these brain structures during ageing that can be directly related to cognitive decline in young and aged animals. We also discuss the influence of the hormonal status on these age-related alterations and recent progress in the development of therapeutic strategies to limit the impact of ageing on memory and cognition in humans.

UR - http://www.scopus.com/inward/record.url?scp=84858702953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858702953&partnerID=8YFLogxK

U2 - 10.1038/nrn3200

DO - 10.1038/nrn3200

M3 - Review article

VL - 13

SP - 240

EP - 250

JO - Nature reviews. Neuroscience

JF - Nature reviews. Neuroscience

SN - 1471-003X

IS - 4

ER -