The afferennt connections of the substantia innominata in the monkey, Macaca fascicularis

F. T. Russchen, David G Amaral, J. L. Price

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

The afferent connections of the substantia innominata and the magnocellular nuclei within it (the nucleus of the horizontal limb of the diagonal band, NHDB, and the nucleus basalis of Meynert, NBM) have been studied with anterograde and retrograde axonal tracing techniques. Prominent inputs arise in the amygdaloid complex, restricted areas of the cerebral cortex, parts of the thalamus and hypothalamus, and nuclei of the lower brainstem. Autoradiographic tracing experiments indicate that the amygdaloid fibers are distributed throughout the NHDB and the NBM, and to a lesser extent to the ventral pallidum. Relatively few fibers innervate the more medially located nucleus of the vertical limb of the diagonal band (NVDB) and the medial septal nucleus. Visualization of the amygdalofugal fibers with the greater PHA-L (Phaseolus vulgaris leuco-agglutinin) shows that they have varicosities resembling boutons en passant along their length in the substantia innominata. Retrograde tracing experiments using WGA-HRP indicate that the cells of origin of the projection from the amygdala are concentrated in the parvicellular basal nucleus, the caudal part of the magnocellular basal nucleus, the magnocellular accessory basal nucleus, and the central nucleus. Relatively few fibers to the substantia innominata arise in the rostrodorsal part of the magnocellular basal nucleus, or in the lateral or parvicellular accessory basal nuclei. Cortisal cells projecting to the substantia innominata were retrogradely labeled in the orbitofrontal cortex (including areas 11-14 and 25), the rostral insula (especially the agranular area), the rostroventral temporal cortex (including areas 35, 36, and parts of TG and TE), and the piriform and entorhinal cortices. The projections from the orbital and rostral temporal cortex were confirmed with anterograde tracers. Projections to the substantia innominata were not found from the more lateral, dorsal or caudal parts of the cerebral cortex, although fibers from temporal area TA may pass through the dendritic field of the most caudal cells of the NMB. Diencephalic cells projecting to the substantia innominata are distributed diffusely throughout the preoptic area and hypothalamus, with higher concentration in the lateral preoptic area and in the pre-, supra-, and tuberomammillary nuclei. Cells are also found in the midline thalamic nuclei and in the region between the peripeduncular and subparafascicular nuclei. In the brainstem, high concentrations of cells projecting to the subtantia innominata are located in the dorsal and median raphe nuclei, the parabrachial nuclei, and the ventral tegmental area and pars compacta of the substantia nigra. There are also cells in the central gray and pedunculopontine region, the reticular formation, the locus coeruleus, and the nuceus of the solitary tract.

Original languageEnglish (US)
Pages (from-to)1-27
Number of pages27
JournalJournal of Comparative Neurology
Volume242
Issue number1
StatePublished - 1985
Externally publishedYes

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Substantia Innominata
Macaca fascicularis
Haplorhini
Basal Nucleus of Meynert
Preoptic Area
Temporal Lobe
Cerebral Cortex
Hypothalamus
Brain Stem
Extremities
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Tegmentum Mesencephali
Midline Thalamic Nuclei
Lateral Hypothalamic Area
Septal Nuclei
Entorhinal Cortex
Ventral Tegmental Area
Reticular Formation
Phaseolus
Locus Coeruleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The afferennt connections of the substantia innominata in the monkey, Macaca fascicularis. / Russchen, F. T.; Amaral, David G; Price, J. L.

In: Journal of Comparative Neurology, Vol. 242, No. 1, 1985, p. 1-27.

Research output: Contribution to journalArticle

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