The adult asthmatic

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Asthma in the adult patient is a complex clinical syndrome. Multiple patient phenotypes and subphenotypes exist that contribute to disease heterogeneity. Whether adult asthma begins in utero, develops in childhood, or manifests for the first time in adulthood is not completely understood, nor are the mechanisms fully delineated. In this chapter, we update definitions that apply to this group, emphasize epidemiologic factors and pathogenic mechanisms, diagnosis, therapeutic options, and controversies regarding drug safety. Finally, we provide a brief discussion of biomarker technologies and novel therapies with the potential to impact adult-onset asthma outcomes.

Original languageEnglish (US)
Pages (from-to)138-155
Number of pages18
JournalClinical Reviews in Allergy and Immunology
Volume43
Issue number1-2
DOIs
StatePublished - Aug 2012

Keywords

  • Adult-onset asthma
  • Asthma cluster(s)
  • Controller medication
  • COPD
  • Drug safety
  • Guidelines
  • Heterogenous
  • Investigational therapies
  • Late-onset asthma
  • New paradigm
  • Novel treatments
  • Patient compliance
  • Phenotype
  • Severe asthma
  • Statin
  • Step-down therapy
  • Step-up therapy
  • Subphenotype

ASJC Scopus subject areas

  • Immunology and Allergy

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