The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice

Cynthia A. Janusz, Robert F Berman

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adenosine (6-100 μM) reduced the duration of epileptiform bursting in a dose-related manner, which was reversible upon washout of adenosine. Application of PD 81,723 (50-100 μM) also resulted in a dose-dependent reduction in the duration of the triggered burst, which was irreversible. These results demonstrate anticonvulsant activity of adenosine and the adenosine binding enhancer, PD 81,723, in the low magnesium model of epilepsy.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalBrain Research
Volume619
Issue number1-2
DOIs
StatePublished - Aug 13 1993
Externally publishedYes

Keywords

  • Adenosine
  • Anticonvulsant
  • Binding enhancer
  • Hippocampal slice
  • Magnesium
  • Seizure

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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