Abstract
The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adenosine (6-100 μM) reduced the duration of epileptiform bursting in a dose-related manner, which was reversible upon washout of adenosine. Application of PD 81,723 (50-100 μM) also resulted in a dose-dependent reduction in the duration of the triggered burst, which was irreversible. These results demonstrate anticonvulsant activity of adenosine and the adenosine binding enhancer, PD 81,723, in the low magnesium model of epilepsy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-136 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 619 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Aug 13 1993 |
| Externally published | Yes |
Keywords
- Adenosine
- Anticonvulsant
- Binding enhancer
- Hippocampal slice
- Magnesium
- Seizure
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Janusz, C. A., & Berman, R. F. (1993). The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice. Brain Research, 619(1-2), 131-136. https://doi.org/10.1016/0006-8993(93)91604-Q