Abstract
The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adenosine (6-100 μM) reduced the duration of epileptiform bursting in a dose-related manner, which was reversible upon washout of adenosine. Application of PD 81,723 (50-100 μM) also resulted in a dose-dependent reduction in the duration of the triggered burst, which was irreversible. These results demonstrate anticonvulsant activity of adenosine and the adenosine binding enhancer, PD 81,723, in the low magnesium model of epilepsy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-136 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 619 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Aug 13 1993 |
| Externally published | Yes |
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Keywords
- Adenosine
- Anticonvulsant
- Binding enhancer
- Hippocampal slice
- Magnesium
- Seizure
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice. / Janusz, Cynthia A.; Berman, Robert F.
In: Brain Research, Vol. 619, No. 1-2, 13.08.1993, p. 131-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice
AU - Janusz, Cynthia A.
AU - Berman, Robert F
PY - 1993/8/13
Y1 - 1993/8/13
N2 - The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adenosine (6-100 μM) reduced the duration of epileptiform bursting in a dose-related manner, which was reversible upon washout of adenosine. Application of PD 81,723 (50-100 μM) also resulted in a dose-dependent reduction in the duration of the triggered burst, which was irreversible. These results demonstrate anticonvulsant activity of adenosine and the adenosine binding enhancer, PD 81,723, in the low magnesium model of epilepsy.
AB - The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adenosine (6-100 μM) reduced the duration of epileptiform bursting in a dose-related manner, which was reversible upon washout of adenosine. Application of PD 81,723 (50-100 μM) also resulted in a dose-dependent reduction in the duration of the triggered burst, which was irreversible. These results demonstrate anticonvulsant activity of adenosine and the adenosine binding enhancer, PD 81,723, in the low magnesium model of epilepsy.
KW - Adenosine
KW - Anticonvulsant
KW - Binding enhancer
KW - Hippocampal slice
KW - Magnesium
KW - Seizure
UR - http://www.scopus.com/inward/record.url?scp=0027247826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027247826&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(93)91604-Q
DO - 10.1016/0006-8993(93)91604-Q
M3 - Article
C2 - 8374770
AN - SCOPUS:0027247826
VL - 619
SP - 131
EP - 136
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -