The acetazolamide challenge: Imaging techniques designed to evaluate cerebral blood flow reserve

J. Rogg, M. Rutigliano, H. Yonas, D. W. Johnson, S. Pentheny, Richard E Latchaw

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status. The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalAmerican Journal of Roentgenology
Volume153
Issue number3
StatePublished - 1989
Externally publishedYes

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Cerebrovascular Circulation
Acetazolamide
Xenon
Blood Vessels
Hemodynamics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

The acetazolamide challenge : Imaging techniques designed to evaluate cerebral blood flow reserve. / Rogg, J.; Rutigliano, M.; Yonas, H.; Johnson, D. W.; Pentheny, S.; Latchaw, Richard E.

In: American Journal of Roentgenology, Vol. 153, No. 3, 1989, p. 605-612.

Research output: Contribution to journalArticle

Rogg, J, Rutigliano, M, Yonas, H, Johnson, DW, Pentheny, S & Latchaw, RE 1989, 'The acetazolamide challenge: Imaging techniques designed to evaluate cerebral blood flow reserve', American Journal of Roentgenology, vol. 153, no. 3, pp. 605-612.
Rogg, J. ; Rutigliano, M. ; Yonas, H. ; Johnson, D. W. ; Pentheny, S. ; Latchaw, Richard E. / The acetazolamide challenge : Imaging techniques designed to evaluate cerebral blood flow reserve. In: American Journal of Roentgenology. 1989 ; Vol. 153, No. 3. pp. 605-612.
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