The acetazolamide challenge: imaging techniques designed to evaluate cerebral blood flow reserve

J. Rogg, M. Rutigliano, H. Yonas, D. W. Johnson, S. Pentheny, Richard E Latchaw

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status. The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.

Original languageEnglish (US)
Pages (from-to)803-810
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume10
Issue number4
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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