The A-current: how ubiquitous a feature of excitable cells is it?

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Abstract

The membranes of most excitable cells contain a distinct set of potassium channels that rapidly open and close following depolarization, giving rise to a transient outward membrane current (IA). This current seems to play an important role in allowing neurons to encode graded depolarization into spike train information; in action potential repolarization, particularly in cardiac muscle cells; and in several aspects of synaptic transmission. As a modifier of the responsiveness of postsynaptic neurons to synaptic potentials,IA is a critical determinant of the integrative behavior of certain neural networks. Recent studies indicate that IA can be physiologically modulated by synaptic influences and during learning. The discovery of Drosophila mutants where IA is defective or absent provides the hope that this may soon be the first potassium channel amenable to structural analysis by molecular genetic techniques.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalTrends in Neurosciences
Volume8
Issue numberC
DOIs
StatePublished - 1985
Externally publishedYes

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Potassium Channels
Hope
Neurons
Genetic Techniques
Synaptic Potentials
Membranes
Cardiac Myocytes
Synaptic Transmission
Action Potentials
Drosophila
Molecular Biology
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The A-current : how ubiquitous a feature of excitable cells is it? / Rogawski, Michael A.

In: Trends in Neurosciences, Vol. 8, No. C, 1985, p. 214-219.

Research output: Contribution to journalArticle

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