Abstract
The membranes of most excitable cells contain a distinct set of potassium channels that rapidly open and close following depolarization, giving rise to a transient outward membrane current (IA). This current seems to play an important role in allowing neurons to encode graded depolarization into spike train information; in action potential repolarization, particularly in cardiac muscle cells; and in several aspects of synaptic transmission. As a modifier of the responsiveness of postsynaptic neurons to synaptic potentials,IA is a critical determinant of the integrative behavior of certain neural networks. Recent studies indicate that IA can be physiologically modulated by synaptic influences and during learning. The discovery of Drosophila mutants where IA is defective or absent provides the hope that this may soon be the first potassium channel amenable to structural analysis by molecular genetic techniques.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-219 |
| Number of pages | 6 |
| Journal | Trends in Neurosciences |
| Volume | 8 |
| Issue number | C |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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The A-current : how ubiquitous a feature of excitable cells is it? / Rogawski, Michael A.
In: Trends in Neurosciences, Vol. 8, No. C, 1985, p. 214-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The A-current
T2 - how ubiquitous a feature of excitable cells is it?
AU - Rogawski, Michael A
PY - 1985
Y1 - 1985
N2 - The membranes of most excitable cells contain a distinct set of potassium channels that rapidly open and close following depolarization, giving rise to a transient outward membrane current (IA). This current seems to play an important role in allowing neurons to encode graded depolarization into spike train information; in action potential repolarization, particularly in cardiac muscle cells; and in several aspects of synaptic transmission. As a modifier of the responsiveness of postsynaptic neurons to synaptic potentials,IA is a critical determinant of the integrative behavior of certain neural networks. Recent studies indicate that IA can be physiologically modulated by synaptic influences and during learning. The discovery of Drosophila mutants where IA is defective or absent provides the hope that this may soon be the first potassium channel amenable to structural analysis by molecular genetic techniques.
AB - The membranes of most excitable cells contain a distinct set of potassium channels that rapidly open and close following depolarization, giving rise to a transient outward membrane current (IA). This current seems to play an important role in allowing neurons to encode graded depolarization into spike train information; in action potential repolarization, particularly in cardiac muscle cells; and in several aspects of synaptic transmission. As a modifier of the responsiveness of postsynaptic neurons to synaptic potentials,IA is a critical determinant of the integrative behavior of certain neural networks. Recent studies indicate that IA can be physiologically modulated by synaptic influences and during learning. The discovery of Drosophila mutants where IA is defective or absent provides the hope that this may soon be the first potassium channel amenable to structural analysis by molecular genetic techniques.
UR - http://www.scopus.com/inward/record.url?scp=0021871062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021871062&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(85)90082-7
DO - 10.1016/0166-2236(85)90082-7
M3 - Article
AN - SCOPUS:0021871062
VL - 8
SP - 214
EP - 219
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - C
ER -