The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

Ruta Sahasrabudhe, Ana Estrada, Paul Lott, Lynn Martin, Guadalupe Polanco Echeverry, Alejandro Velez, Gila Neta, Meiko Takahasi, Vladimir Saenko, Norisato Mitsutake, Emma Jaeguer, Carlos Simon Duque, Alejandro Rios, Mabel Bohorquez, Rodrigo Prieto, Angel Criollo, Magdalena Echeverry, Ian Tomlinson, Luis Carvajal-Carmona

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls.We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11-1.27, P=4.03×10-7), Japan (OR=1.20, 95% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10-7, OR=1.13, 95% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

Original languageEnglish (US)
Pages (from-to)841-849
Number of pages9
JournalEndocrine-Related Cancer
Volume22
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • 8q24
  • Genetic susceptibility
  • Rs6983267G
  • Thyroid cancer

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

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    Sahasrabudhe, R., Estrada, A., Lott, P., Martin, L., Echeverry, G. P., Velez, A., Neta, G., Takahasi, M., Saenko, V., Mitsutake, N., Jaeguer, E., Duque, C. S., Rios, A., Bohorquez, M., Prieto, R., Criollo, A., Echeverry, M., Tomlinson, I., & Carvajal-Carmona, L. (2015). The 8q24 rs6983267G variant is associated with increased thyroid cancer risk. Endocrine-Related Cancer, 22(5), 841-849. https://doi.org/10.1530/ERC-15-0081