The 83-kilodalton antigen of Borrelia burgdorferi which stimulates immunoglobulin M (IgM) and IgG responses in infected hosts is expressed by a chromosomal gene

Rance B Lefebvre, G. C. Perng, R. C. Johnson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We report the cloning and characterization of a chromosomal gene from Borrelia burgdorferi expressing an 83-kilodalton protein antigen in Escherichia coli. The antigen reacted strongly with antisera from two human Lyme disease patients. The chromosomal gene was expressed in a 6.5-kilobase-pair ClaI fragment cloned in a variable-reading-frame plasmid vector.

Original languageEnglish (US)
Pages (from-to)1673-1675
Number of pages3
JournalJournal of Clinical Microbiology
Volume28
Issue number7
StatePublished - 1990

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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