The 6-minute walk test as a new outcome measure in duchenne muscular dystrophy

Craig M McDonald; Erik K Henricson; Jay J. Han; R. Ted Abresch; Alina Nicorici; Gary L. Elfring; Leone Atkinson; Allen Reha; Samit Hirawat; Langdon L. Miller

doi:10.1002/mus.21544

The 6-minute walk test as a new outcome measure in duchenne muscular dystrophy

Craig M McDonald, Erik K Henricson, Jay J. Han, R. Ted Abresch, Alina Nicorici, Gary L. Elfring, Leone Atkinson, Allen Reha, Samit Hirawat, Langdon L. Miller

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Abstract

Walking abnormalities are prominent in Duchenne muscular dystrophy (DMD). We modified the 6-minute walk test (6MWT) for use as an outcome measure in patients with DMD and evaluated its performance in 21 ambulatory boys with DMD and 34 healthy boys, ages 4 to 12 years. Boys with DMD were tested twice, -1 week apart; controls were tested once. The groups had similar age, height, and weight. All tests were completed. Boys who fell recovered rapidly from falls without injury. Mean ± SD [range] 6-minute walk distance (6MWD) was lower in boys with DMD than in controls (366 ± 83 [125-481] m vs. 621 ± 68 [479-754] m; P < 0.0001; unpaired t-test). Test-retest correlation for boys with DMD was high (r = 0.91). Stride length (R² = 0.89; P < 0.0001) was the major determinant of 6MWD for both boys with DMD and controls. A modified 6MWT is feasible and safe, documents disease-related limitations on ambulation, is reproducible, and offers a new outcome measure for DMD natural history and therapeutic trials.

Original language	English (US)
Pages (from-to)	500-510
Number of pages	11
Journal	Muscle and Nerve
Volume	41
Issue number	4
DOIs	https://doi.org/10.1002/mus.21544
State	Published - Apr 2010

Keywords

6-minute walk test
Case-control study
Child
Duchenne
Gait disorder
Muscular dystrophy
Neurologic

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)
Physiology

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The 6-minute walk test as a new outcome measure in duchenne muscular dystrophy. / McDonald, Craig M ; Henricson, Erik K; Han, Jay J.; Abresch, R. Ted; Nicorici, Alina; Elfring, Gary L.; Atkinson, Leone; Reha, Allen; Hirawat, Samit; Miller, Langdon L.

In: Muscle and Nerve, Vol. 41, No. 4, 04.2010, p. 500-510.

Research output: Contribution to journal › Article › peer-review

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