The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40

P. K. Ghosh; V. B. Reddy; J. Swinscoe; Prabhakara V Choudary; P. Lebowitz; S. M. Weissman

The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40

P. K. Ghosh, V. B. Reddy, J. Swinscoe, Prabhakara V Choudary, P. Lebowitz, S. M. Weissman

Research output: Contribution to journal › Article › peer-review

Abstract

The 16 S mRNA that directs the synthesis of VP1, the major structural protein of Simian virus 40 (SV40), is composed of a leader sequence of 203 nucleotides joined to a transcript that contains all the codons for VP1. The leader is transcribed from DNA between 0.723 and 0.762 map units while the VP1 coding transcript is copied from DNA from 0.94 to 0.17 map units. The leader sequence joins the transcript of the coding region at a position 42 nucleotides upstream from the initiator codon for CP1 by a 3':5'-phosphodiester linkage. Longer leader sequences also occur in a portion of SV40 late mRNA.

Original language	English (US)
Pages (from-to)	3643-3647
Number of pages	5
Journal	Journal of Biological Chemistry
Volume	253
Issue number	10
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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title = "The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40",

abstract = "The 16 S mRNA that directs the synthesis of VP1, the major structural protein of Simian virus 40 (SV40), is composed of a leader sequence of 203 nucleotides joined to a transcript that contains all the codons for VP1. The leader is transcribed from DNA between 0.723 and 0.762 map units while the VP1 coding transcript is copied from DNA from 0.94 to 0.17 map units. The leader sequence joins the transcript of the coding region at a position 42 nucleotides upstream from the initiator codon for CP1 by a 3':5'-phosphodiester linkage. Longer leader sequences also occur in a portion of SV40 late mRNA.",

author = "Ghosh, {P. K.} and Reddy, {V. B.} and J. Swinscoe and Choudary, {Prabhakara V} and P. Lebowitz and Weissman, {S. M.}",

year = "1978",

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pages = "3643--3647",

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T1 - The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40

AU - Ghosh, P. K.

AU - Reddy, V. B.

AU - Swinscoe, J.

AU - Choudary, Prabhakara V

AU - Lebowitz, P.

AU - Weissman, S. M.

PY - 1978

Y1 - 1978

N2 - The 16 S mRNA that directs the synthesis of VP1, the major structural protein of Simian virus 40 (SV40), is composed of a leader sequence of 203 nucleotides joined to a transcript that contains all the codons for VP1. The leader is transcribed from DNA between 0.723 and 0.762 map units while the VP1 coding transcript is copied from DNA from 0.94 to 0.17 map units. The leader sequence joins the transcript of the coding region at a position 42 nucleotides upstream from the initiator codon for CP1 by a 3':5'-phosphodiester linkage. Longer leader sequences also occur in a portion of SV40 late mRNA.

AB - The 16 S mRNA that directs the synthesis of VP1, the major structural protein of Simian virus 40 (SV40), is composed of a leader sequence of 203 nucleotides joined to a transcript that contains all the codons for VP1. The leader is transcribed from DNA between 0.723 and 0.762 map units while the VP1 coding transcript is copied from DNA from 0.94 to 0.17 map units. The leader sequence joins the transcript of the coding region at a position 42 nucleotides upstream from the initiator codon for CP1 by a 3':5'-phosphodiester linkage. Longer leader sequences also occur in a portion of SV40 late mRNA.

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AN - SCOPUS:0018104072

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 10

ER -

The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40

Abstract

ASJC Scopus subject areas

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