The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40

P. K. Ghosh, V. B. Reddy, J. Swinscoe, Prabhakara V Choudary, P. Lebowitz, S. M. Weissman

Research output: Contribution to journalArticle

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Abstract

The 16 S mRNA that directs the synthesis of VP1, the major structural protein of Simian virus 40 (SV40), is composed of a leader sequence of 203 nucleotides joined to a transcript that contains all the codons for VP1. The leader is transcribed from DNA between 0.723 and 0.762 map units while the VP1 coding transcript is copied from DNA from 0.94 to 0.17 map units. The leader sequence joins the transcript of the coding region at a position 42 nucleotides upstream from the initiator codon for CP1 by a 3':5'-phosphodiester linkage. Longer leader sequences also occur in a portion of SV40 late mRNA.

Original languageEnglish (US)
Pages (from-to)3643-3647
Number of pages5
JournalJournal of Biological Chemistry
Volume253
Issue number10
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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    Ghosh, P. K., Reddy, V. B., Swinscoe, J., Choudary, P. V., Lebowitz, P., & Weissman, S. M. (1978). The 5'-terminal leader sequence of late 16 S mRNA from cells infected with Simian virus 40. Journal of Biological Chemistry, 253(10), 3643-3647.