The β2-adrenergic receptor is a global regulator of wound healing in vivo

Research output: Contribution to journalArticle

Abstract

In a study, colonies of FVB mice to investigate the role of the β2-AR in murine wound healing in vivo was conducted. Murine keratinocytes and dermal fibroblasts were isolated from both WT and KO neonates and the effect of β2-AR ligands on murine cell migration, ERK phosphorylation and galvanotaxis was studied. To full-thickness wound were created on the mice and treated daily. Results show that β2-AR activation decreased both ERK phosphorylation and the migratory capacity of WT murine K, while blinding them to an applied electric field. It was demonstrated that β2-AR agonist treatment delays, while β2-AR antagonist treatment augments wound healing in vivo by modulating both re-epithelialization and wound contraction.

Original languageEnglish (US)
Pages (from-to)233-234
Number of pages2
JournalMCB Molecular and Cellular Biomechanics
Volume3
Issue number4
StatePublished - Dec 2006

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Wound Healing
Adrenergic Receptors
Phosphorylation
Re-Epithelialization
Wounds and Injuries
Keratinocytes
Cell Movement
Fibroblasts
Ligands
Skin
Therapeutics
Taxis Response

ASJC Scopus subject areas

  • Cell Biology
  • Biophysics
  • Molecular Biology
  • Molecular Medicine

Cite this

The β2-adrenergic receptor is a global regulator of wound healing in vivo. / Pullar, C. E.; Isseroff, Roslyn Rivkah.

In: MCB Molecular and Cellular Biomechanics, Vol. 3, No. 4, 12.2006, p. 233-234.

Research output: Contribution to journalArticle

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