Thalamocortical connections of the parietal ventral area (PV) and the second somatosensory area (S2) in macaque monkeys

Elizabeth Disbrow, Evangelos Litinas, Gregg H. Recanzone, Daniel Slutsky, Leah Krubitzer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Neuroanatomical tracers were injected into two functionally distinct areas in the lateral sulcus of macaque monkeys, the parietal ventral area (PV) and the second somatosensory area (S2). Three of the four injection sites were electrophysiologically determined by defining the receptive fields of neurons at the injection site prior to the placement of the anatomical tracers. Additionally, all locations were confirmed myeloarchitectonically. Labeled cell bodies and axon terminals were identified in the ipsilateral dorsal thalamus and related to nuclear boundaries in tissue stained for cytochrome oxidase (CO) and Nissl substance. Our results indicate that PV receives substantial input from the inferior division of the ventral posterior nucleus (VPi), the anterior pulvinar (Pla), and from the ventral portion of the magnocellular division of the mediodorsal nucleus (MDm), which also is interconnected with prefrontal cortex, the entorhinal cortex and the amygdala. S2 receives input predominantly from VPi, the ventral posterior superior nucleus (VPs), and Pla. These results indicate that PV and S2 are involved in processing inputs from deep receptors in the muscles and joints. Because PV and S2 receive little if any cutaneous input from the thalamus, cutaneous input to these fields must arise mainly through cortical connections. Connectional data supports the proposition that PV and S2 integrate motor and somatic information necessary for proprioception, goal directed reaching and grasping and tactile object identification. Further, PV may play a role in tactile learning and memory.

Original languageEnglish (US)
Pages (from-to)289-302
Number of pages14
JournalThalamus and Related Systems
Volume1
Issue number4
StatePublished - 2002

Fingerprint

Ventral Thalamic Nuclei
Macaca
Haplorhini
Pulvinar
Touch
Thalamus
Mediodorsal Thalamic Nucleus
Proprioception
Skin
Entorhinal Cortex
Injections
Presynaptic Terminals
Electron Transport Complex IV
Amygdala
Prefrontal Cortex
Joints
Learning
Neurons
Muscles

Keywords

  • Electrophysiology
  • Sensorimotor integration
  • Somatosensory neocortex
  • Sylvian fissure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Disbrow, E., Litinas, E., Recanzone, G. H., Slutsky, D., & Krubitzer, L. (2002). Thalamocortical connections of the parietal ventral area (PV) and the second somatosensory area (S2) in macaque monkeys. Thalamus and Related Systems, 1(4), 289-302.

Thalamocortical connections of the parietal ventral area (PV) and the second somatosensory area (S2) in macaque monkeys. / Disbrow, Elizabeth; Litinas, Evangelos; Recanzone, Gregg H.; Slutsky, Daniel; Krubitzer, Leah.

In: Thalamus and Related Systems, Vol. 1, No. 4, 2002, p. 289-302.

Research output: Contribution to journalArticle

Disbrow, E, Litinas, E, Recanzone, GH, Slutsky, D & Krubitzer, L 2002, 'Thalamocortical connections of the parietal ventral area (PV) and the second somatosensory area (S2) in macaque monkeys', Thalamus and Related Systems, vol. 1, no. 4, pp. 289-302.
Disbrow, Elizabeth ; Litinas, Evangelos ; Recanzone, Gregg H. ; Slutsky, Daniel ; Krubitzer, Leah. / Thalamocortical connections of the parietal ventral area (PV) and the second somatosensory area (S2) in macaque monkeys. In: Thalamus and Related Systems. 2002 ; Vol. 1, No. 4. pp. 289-302.
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