Texture analysis of cartilage T2 maps: Individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls - data from the osteoarthritis initiative

Gabby B. Joseph, Thomas Baum, Julio Carballido-Gamio, Lorenzo Nardo, Warapat Virayavanich, Hamza Alizai, John A. Lynch, Charles E. McCulloch, Sharmila Majumdar, Thomas M. Link

Research output: Contribution to journalArticle

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Abstract

Introduction: The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage T^2 relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) T^2 relaxation times between subjects with and without risk factors for OA, (ii) to determine the relationship between MR cartilage T^2 parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and T^2 relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods: Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the OAI incidence and control cohorts, respectively. The specific inclusion criteria for this study was: (1) age range 45-55 years (2) body mass index (BMI) of 19-27 kg/m^2 (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage T^2 mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results: While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, BME, meniscus lesions) between controls and subjects at risk for OA, T^2 parameters (mean T^2, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage T^2 parameters was evident. Conclusions: Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous T^2 values than controls, and that T^2 parameters are associated with morphologic degeneration.

Original languageEnglish (US)
JournalArthritis Research & Therapy
DOIs
StateAccepted/In press - Sep 20 2011
Externally publishedYes

Fingerprint

Osteoarthritis
Cartilage
Knee
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Body Mass Index
Ontario
Bone Marrow
Pain
Incidence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Rheumatology
  • Medicine(all)

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Texture analysis of cartilage T2 maps : Individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls - data from the osteoarthritis initiative. / Joseph, Gabby B.; Baum, Thomas; Carballido-Gamio, Julio; Nardo, Lorenzo; Virayavanich, Warapat; Alizai, Hamza; Lynch, John A.; McCulloch, Charles E.; Majumdar, Sharmila; Link, Thomas M.

In: Arthritis Research & Therapy, 20.09.2011.

Research output: Contribution to journalArticle

Joseph, Gabby B. ; Baum, Thomas ; Carballido-Gamio, Julio ; Nardo, Lorenzo ; Virayavanich, Warapat ; Alizai, Hamza ; Lynch, John A. ; McCulloch, Charles E. ; Majumdar, Sharmila ; Link, Thomas M. / Texture analysis of cartilage T2 maps : Individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls - data from the osteoarthritis initiative. In: Arthritis Research & Therapy. 2011.
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abstract = "Introduction: The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage T^2 relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) T^2 relaxation times between subjects with and without risk factors for OA, (ii) to determine the relationship between MR cartilage T^2 parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and T^2 relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods: Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the OAI incidence and control cohorts, respectively. The specific inclusion criteria for this study was: (1) age range 45-55 years (2) body mass index (BMI) of 19-27 kg/m^2 (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage T^2 mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results: While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, BME, meniscus lesions) between controls and subjects at risk for OA, T^2 parameters (mean T^2, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage T^2 parameters was evident. Conclusions: Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous T^2 values than controls, and that T^2 parameters are associated with morphologic degeneration.",
author = "Joseph, {Gabby B.} and Thomas Baum and Julio Carballido-Gamio and Lorenzo Nardo and Warapat Virayavanich and Hamza Alizai and Lynch, {John A.} and McCulloch, {Charles E.} and Sharmila Majumdar and Link, {Thomas M.}",
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T2 - Individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls - data from the osteoarthritis initiative

AU - Joseph, Gabby B.

AU - Baum, Thomas

AU - Carballido-Gamio, Julio

AU - Nardo, Lorenzo

AU - Virayavanich, Warapat

AU - Alizai, Hamza

AU - Lynch, John A.

AU - McCulloch, Charles E.

AU - Majumdar, Sharmila

AU - Link, Thomas M.

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