Tetramethylenedisulfotetramine

C. N. Banks, D. Yang, Pamela J Lein, Michael A Rogawski

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991. TETS is, however, still available illegally, primarily in rural China, and is responsible for accidental and intentional poisonings that cause a significant number of human deaths annually. TETS induces convulsive seizures mediated by antagonism of γ-amino-butyric acid (GABA)-mediated chloride channels. There are no known antidotes for TETS poisoning, and in cases of severe TETS intoxication that progress to status epilepticus, prognosis is poor even with aggressive anti-convulsant treatment.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Toxicology
Subtitle of host publicationThird Edition
PublisherElsevier
Pages509-511
Number of pages3
ISBN (Electronic)9780123864543
ISBN (Print)9780123864550
DOIs
StatePublished - Jan 1 2014

Keywords

  • China
  • Chloride channels
  • Convulsant
  • GABA receptor antagonist
  • Neurotoxicant
  • Rodenticide
  • Seizures
  • Status epilepticus
  • Tetramine
  • TETS

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Banks, C. N., Yang, D., Lein, P. J., & Rogawski, M. A. (2014). Tetramethylenedisulfotetramine. In Encyclopedia of Toxicology: Third Edition (pp. 509-511). Elsevier. https://doi.org/10.1016/B978-0-12-386454-3.01055-1