Tetramethylenedisulfotetramine

C. N. Banks; D. Yang; Pamela J Lein; Michael A Rogawski

doi:10.1016/B978-0-12-386454-3.01055-1

Tetramethylenedisulfotetramine

C. N. Banks, D. Yang, Pamela J Lein, Michael A Rogawski

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991. TETS is, however, still available illegally, primarily in rural China, and is responsible for accidental and intentional poisonings that cause a significant number of human deaths annually. TETS induces convulsive seizures mediated by antagonism of γ-amino-butyric acid (GABA)-mediated chloride channels. There are no known antidotes for TETS poisoning, and in cases of severe TETS intoxication that progress to status epilepticus, prognosis is poor even with aggressive anti-convulsant treatment.

Original language	English (US)
Title of host publication	Encyclopedia of Toxicology
Subtitle of host publication	Third Edition
Publisher	Elsevier
Pages	509-511
Number of pages	3
ISBN (Electronic)	9780123864543
ISBN (Print)	9780123864550
DOIs	https://doi.org/10.1016/B978-0-12-386454-3.01055-1
State	Published - Jan 1 2014

Keywords

China
Chloride channels
Convulsant
GABA receptor antagonist
Neurotoxicant
Rodenticide
Seizures
Status epilepticus
Tetramine
TETS

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-386454-3.01055-1

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Cite this

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title = "Tetramethylenedisulfotetramine",

abstract = "Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991. TETS is, however, still available illegally, primarily in rural China, and is responsible for accidental and intentional poisonings that cause a significant number of human deaths annually. TETS induces convulsive seizures mediated by antagonism of γ-amino-butyric acid (GABA)-mediated chloride channels. There are no known antidotes for TETS poisoning, and in cases of severe TETS intoxication that progress to status epilepticus, prognosis is poor even with aggressive anti-convulsant treatment.",

keywords = "China, Chloride channels, Convulsant, GABA receptor antagonist, Neurotoxicant, Rodenticide, Seizures, Status epilepticus, Tetramine, TETS",

author = "Banks, {C. N.} and D. Yang and Lein, {Pamela J} and Rogawski, {Michael A}",

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AU - Banks, C. N.

AU - Yang, D.

AU - Lein, Pamela J

AU - Rogawski, Michael A

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N2 - Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991. TETS is, however, still available illegally, primarily in rural China, and is responsible for accidental and intentional poisonings that cause a significant number of human deaths annually. TETS induces convulsive seizures mediated by antagonism of γ-amino-butyric acid (GABA)-mediated chloride channels. There are no known antidotes for TETS poisoning, and in cases of severe TETS intoxication that progress to status epilepticus, prognosis is poor even with aggressive anti-convulsant treatment.

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KW - Chloride channels

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