Tetrahydroaminoacridine blocks voltage-dependent ion channels in hippocampal neurons

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Abstract

Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that may produce functional improvement in patients with Alzheimer's disease. Because of its structural similarity to the potassium channel (A-current) blocking drug 4-aminopyridine (4-AP), it has been speculated that some of the therapeutic benefit of THA might result from inhibition of potassium currents. In the present study, THA produced a dose-dependent, reversible block of the A-current in cultured hippocampal neurons (IC50, 30 μM). However, at similar concentrations it also inhibited other voltage-dependent currents.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalEuropean Journal of Pharmacology
Volume142
Issue number1
DOIs
StatePublished - Oct 6 1987
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Hippocampus
  • Potassium channel
  • Tacrine
  • Tetrahydroaminoacridine
  • Whole cell patch clamp recording

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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