Abstract
Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that may produce functional improvement in patients with Alzheimer's disease. Because of its structural similarity to the potassium channel (A-current) blocking drug 4-aminopyridine (4-AP), it has been speculated that some of the therapeutic benefit of THA might result from inhibition of potassium currents. In the present study, THA produced a dose-dependent, reversible block of the A-current in cultured hippocampal neurons (IC50, 30 μM). However, at similar concentrations it also inhibited other voltage-dependent currents.
Original language | English (US) |
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Pages (from-to) | 169-172 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 142 |
Issue number | 1 |
DOIs | |
State | Published - Oct 6 1987 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Hippocampus
- Potassium channel
- Tacrine
- Tetrahydroaminoacridine
- Whole cell patch clamp recording
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology