Testosterone biotransformation by the isolated perfused canine pancreas

C. Fernandez-del Castillo, V. Diaz-Sanchez, G. Varela-Fascinetto, A. Altamirano, Alberto M Odor, R. M. Lopez-Medrano, G. Robles-Diaz

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


There is strong evidence indicating that the pancreas is under the influence of sex steroid hormones, and that it may even participate in their biosynthesis and metabolism. In the present study, [3H]testosterone was perfused into the isolated canine pancreas, and measured in the effluent with several of its metabolites (5α-dihydrotestosterone, androstenedione, and estradiol). Results show that testosterone is readily transformed by the canine pancreas. The main product found in the effluent is androstenedione. The testis and spleen were also perfused with [3H]testosterone and used as controls. In both cases, this hormone appeared mostly unchanged in the effluent as compared to the pancreatic perfusion (p < 0.0001). From our data, we conclude that the canine pancreas has the capacity to transform sex steroid hormones, and could be considered an extragonadal site of sex steroid biosynthesis.

Original languageEnglish (US)
Pages (from-to)104-111
Number of pages8
Issue number1
StatePublished - 1990
Externally publishedYes


  • Androgens
  • Androstenedione
  • Pancreas perfusion
  • Sex steroids
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology


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