Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days

Fran Balamuth, Andrea T. Cruz, Stephen B. Freedman, Paul T. Ishimine, Aris Garro, Sarah Curtis, Kendra L. Grether-Jones, Aaron S. Miller, Neil G. Uspal, Suzanne M. Schmidt, Samir S. Shah, Lise E. Nigrovic

Research output: Contribution to journalArticlepeer-review

Abstract

In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.

Original languageEnglish (US)
Pages (from-to)E227-E229
JournalPediatric emergency care
Volume37
Issue number5
DOIs
StatePublished - 2021

Keywords

  • cerebral spinal fluid Gram stain
  • infant
  • meningitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine

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