Teratologic evaluation of imipramine hydrochloride in bonnet (Macaca radiata) and rhesus monkeys (Macaca mulatta)

Andrew G Hendrickx

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Imipramine hydrochloride was administered orally twice daily to 18 bonnet and 3 rhesus monkeys between days 23 and 45 of pregnancy for 1–3 or 18–22 days at 1, 2, and 10 times the recommended human dose. No teratologic changes were observed, although signs of maternal toxicity occurred at the high dose level, and the abortion rate was higher than in controls.

Original languageEnglish (US)
Pages (from-to)219-221
Number of pages3
JournalTeratology
Volume11
Issue number2
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

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