Abstract
Corticosteroids are used to treat several human diseases, especially allergies, and inflammatory, dermatologic and salt imbalance conditions. Because of the possibility that treatment for one of these conditions might occur before a mother knows she is pregnant and that an effect may be exerted over a period of time which could encompass the organogenic or sensitive period, it is important to establish the teratogenic effect of these drugs. It has been demonstrated that corticosteroids vary considerably in their teratogenic effects. Of the six corticosteroids tested triamcinolone was found to be one of the most teratogenic. The dosage of triamcinolone required to produce a specific defect, cleft palate, was as different between breeds of rabbits as it was between rabbits and mice. The initial objectives of the present study were to compare the teratogenic effects of this drug in three species of nonhuman primates and to develop an animal model for the study of orocraniofacial defects. Observations in the initial experiments indicated that the thymus was affected at a high frequency in the rhesus and bonnet monkeys; consequently, the experiments were extended to include thymus differentiation during later stages of pregnancy and to determine whether the effects of triamcinolone on the fetus result in permanent teratological effects on the lymphoid system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1661-1665 |
| Number of pages | 5 |
| Journal | Federation Proceedings |
| Volume | 34 |
| Issue number | 8 |
| State | Published - 1975 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Teratogenic effects of triamcinolone on the skeletal and lymphoid systems in nonhuman primates. / Hendrickx, A. G.; Sawyer, R. H.; Terrell, T. G.; Osburn, B. I.; Henrickson, R. V.; Steffek, A. J.
In: Federation Proceedings, Vol. 34, No. 8, 1975, p. 1661-1665.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Teratogenic effects of triamcinolone on the skeletal and lymphoid systems in nonhuman primates
AU - Hendrickx, A. G.
AU - Sawyer, R. H.
AU - Terrell, T. G.
AU - Osburn, B. I.
AU - Henrickson, R. V.
AU - Steffek, A. J.
PY - 1975
Y1 - 1975
N2 - Corticosteroids are used to treat several human diseases, especially allergies, and inflammatory, dermatologic and salt imbalance conditions. Because of the possibility that treatment for one of these conditions might occur before a mother knows she is pregnant and that an effect may be exerted over a period of time which could encompass the organogenic or sensitive period, it is important to establish the teratogenic effect of these drugs. It has been demonstrated that corticosteroids vary considerably in their teratogenic effects. Of the six corticosteroids tested triamcinolone was found to be one of the most teratogenic. The dosage of triamcinolone required to produce a specific defect, cleft palate, was as different between breeds of rabbits as it was between rabbits and mice. The initial objectives of the present study were to compare the teratogenic effects of this drug in three species of nonhuman primates and to develop an animal model for the study of orocraniofacial defects. Observations in the initial experiments indicated that the thymus was affected at a high frequency in the rhesus and bonnet monkeys; consequently, the experiments were extended to include thymus differentiation during later stages of pregnancy and to determine whether the effects of triamcinolone on the fetus result in permanent teratological effects on the lymphoid system.
AB - Corticosteroids are used to treat several human diseases, especially allergies, and inflammatory, dermatologic and salt imbalance conditions. Because of the possibility that treatment for one of these conditions might occur before a mother knows she is pregnant and that an effect may be exerted over a period of time which could encompass the organogenic or sensitive period, it is important to establish the teratogenic effect of these drugs. It has been demonstrated that corticosteroids vary considerably in their teratogenic effects. Of the six corticosteroids tested triamcinolone was found to be one of the most teratogenic. The dosage of triamcinolone required to produce a specific defect, cleft palate, was as different between breeds of rabbits as it was between rabbits and mice. The initial objectives of the present study were to compare the teratogenic effects of this drug in three species of nonhuman primates and to develop an animal model for the study of orocraniofacial defects. Observations in the initial experiments indicated that the thymus was affected at a high frequency in the rhesus and bonnet monkeys; consequently, the experiments were extended to include thymus differentiation during later stages of pregnancy and to determine whether the effects of triamcinolone on the fetus result in permanent teratological effects on the lymphoid system.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016791328&partnerID=8YFLogxK
M3 - Article
C2 - 1093887
AN - SCOPUS:0016791328
VL - 34
SP - 1661
EP - 1665
JO - Federation Proceedings
JF - Federation Proceedings
SN - 0014-9446
IS - 8
ER -