Teratogenesis and low copper status resulting from D-penicillamine in rats

Carl L Keen, P. Mark-Savage, B. Lonnerdal, L. S. Hurley

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The teratogenicity of D-penicillamine was studied using the Sprague-Dawley rat. Fetuses from rats fed diets containing 0.83% D-penicillamine during pregnancy had a high incidence of malformations. Maternal and fetal tissue copper levels were significantly lower in the D-penicillamine group than in controls, suggesting that the teratogenicity of the drug may be due in part to the induction of copper deficiency by its chelating properties.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
Issue number2
StatePublished - 1982

ASJC Scopus subject areas

  • Developmental Biology
  • Health, Toxicology and Mutagenesis
  • Embryology
  • Toxicology


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