Tensin: A potential link between the cytoskeleton and signal transduction

Su Hao Lo, Ellen Weisberg, Lan Bo Chen

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Cytoskeletal proteins provide the structural foundation that allows cells to exist in a highly organized manner. Recent evidence suggests that certain cytoskeletal proteins not only maintain structural integrity, but might also be associated with signal transduction and suppression of tumorigenesis. Since the time of the discovery of tensin, a fair amount of data has been gathered which supports the notion that tensin is one such protein possessing these characteristics. In this review, we discuss recent studies that: (1) elucidate a role for tensin in maintenance of cellular structure and signal transduction; (2) implicate tensin as the anchor for actin filaments at the focal adhesion; (3) describe the phosphorylation of tensin; (4) describe potential targets for its Src homology region 2 domain; (5) describe the association between tensin and the nuclear protein p130; and (6) demonstrate that increased tensin expression in a cell line appears to reduce its transformation potential.

Original languageEnglish (US)
Pages (from-to)817-823
Number of pages7
JournalBioEssays
Volume16
Issue number11
StatePublished - 1994
Externally publishedYes

Fingerprint

cytoskeletal proteins
Signal transduction
Cytoskeletal Proteins
cytoskeleton
Cytoskeleton
signal transduction
Signal Transduction
Phosphorylation
nuclear proteins
cell structures
Structural integrity
Nuclear Proteins
Anchors
microfilaments
carcinogenesis
adhesion
Actins
phosphorylation
Adhesion
Cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Neuroscience (miscellaneous)

Cite this

Tensin : A potential link between the cytoskeleton and signal transduction. / Lo, Su Hao; Weisberg, Ellen; Chen, Lan Bo.

In: BioEssays, Vol. 16, No. 11, 1994, p. 817-823.

Research output: Contribution to journalArticle

Lo, SH, Weisberg, E & Chen, LB 1994, 'Tensin: A potential link between the cytoskeleton and signal transduction', BioEssays, vol. 16, no. 11, pp. 817-823.
Lo, Su Hao ; Weisberg, Ellen ; Chen, Lan Bo. / Tensin : A potential link between the cytoskeleton and signal transduction. In: BioEssays. 1994 ; Vol. 16, No. 11. pp. 817-823.
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