Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion

Koen K.A. Van Rompay, Marta Marthas, Norbert Bischofberger

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We investigated if the antiviral drug tenofovir has immunomodulatory effects in macaques, similar to those described in murine models. While in vivo experiments were complicated by high individual and temporal variability of immune parameters, tenofovir primed macaque peripheral blood mononuclear cells in vitro for enhanced IL-12 secretion following exposure to bacterial antigens.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalAntiviral Research
Volume63
Issue number2
DOIs
StatePublished - Aug 1 2004

Keywords

  • IL-12
  • In vitro
  • Macaque
  • PMPA
  • Tenofovir

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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