Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion

Koen K.A. Van Rompay, Marta Marthas, Norbert Bischofberger

Research output: Contribution to journalArticle

13 Scopus citations


We investigated if the antiviral drug tenofovir has immunomodulatory effects in macaques, similar to those described in murine models. While in vivo experiments were complicated by high individual and temporal variability of immune parameters, tenofovir primed macaque peripheral blood mononuclear cells in vitro for enhanced IL-12 secretion following exposure to bacterial antigens.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalAntiviral Research
Issue number2
StatePublished - Aug 1 2004



  • IL-12
  • In vitro
  • Macaque
  • PMPA
  • Tenofovir

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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