Teneurins: Transmembrane proteins with fundamental roles in development

Richard P Tucker, Daniela Kenzelmann, Agnieszka Trzebiatowska, Ruth Chiquet-Ehrismann

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Teneurins are a novel family of transmembrane proteins expressed during pattern formation and morphogenesis. Originally discovered as ten-m and ten-a in Drosophila, four vertebrate teneurins as well as a Caenorhabditis elegans homologue were identified. The conserved domain architecture of teneurins includes an intracellular domain containing polyproline motifs. The long extracellular domain consists of eight EGF-like repeats, a region of conserved cysteines and unique YD-repeats. Vertebrate teneurins are most prominently expressed in the developing central nervous system, but are also expressed in developing limbs. In C. elegans, RNAi experiments and studies of mutants reveal that teneurins are required during fundamental developmental processes like cell migration and axon pathfinding. Cell culture experiments suggest that the intracellular domain of teneurins translocates to the nucleus following release from the membrane by proteolytic processing. Interestingly, the human teneurin-1 gene is located on the X-chromosome in a region where several families with X-linked mental retardation are mapped.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume39
Issue number2
DOIs
StatePublished - 2007

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Caenorhabditis elegans
Vertebrates
X-Linked Mental Retardation
Neurology
X Chromosome
Chromosomes
RNA Interference
Morphogenesis
Cell culture
Epidermal Growth Factor
Drosophila
Cell Movement
Cysteine
Proteins
Extremities
Central Nervous System
Cell Culture Techniques
Genes
Experiments
Membranes

Keywords

  • Odd oz
  • Odz
  • Ten-1

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Teneurins : Transmembrane proteins with fundamental roles in development. / Tucker, Richard P; Kenzelmann, Daniela; Trzebiatowska, Agnieszka; Chiquet-Ehrismann, Ruth.

In: International Journal of Biochemistry and Cell Biology, Vol. 39, No. 2, 2007, p. 292-297.

Research output: Contribution to journalArticle

Tucker, Richard P ; Kenzelmann, Daniela ; Trzebiatowska, Agnieszka ; Chiquet-Ehrismann, Ruth. / Teneurins : Transmembrane proteins with fundamental roles in development. In: International Journal of Biochemistry and Cell Biology. 2007 ; Vol. 39, No. 2. pp. 292-297.
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