Teneurins, a transmembrane protein family involved in cell communication during neuronal development

D. Kenzelmann, R. Chiquet-Ehrismann, Richard P Tucker

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Teneurins are a unique family of transmembrane proteins conserved from Caenorhabditis elegans and Drosophila melanogaster to vertebrates, in which four paralogs exist. In vertebrates, teneurin expression is most prominent in the developing brain. Based on their distinct, complementary expression patterns, we suggest a possible function in the establishment of proper connectivity in the brain. Functional studies show that teneurins can stimulate neurite outgrowth, but they might also play a role in axon guidance as well as in target recognition and synaptogenesis, possibly mediated by homophilic interactions. Though teneurins are transmembrane proteins, there is evidence that the intracellular domain has a nuclear function, since it can interact with nuclear proteins and influence transcription. Therefore, we speculate that teneurins might be processed by proteolytic cleavage (possibly regulated intramembrane proteolysis), which is triggered by homophilic interactions or, alternatively, by the binding of a still unknown ligand.

Original languageEnglish (US)
Pages (from-to)1452-1456
Number of pages5
JournalCellular and Molecular Life Sciences
Issue number12
StatePublished - Jun 2007


  • Brain
  • Nervous system
  • Neural circuit
  • Odz
  • Regulated intramembrane proteolysis
  • Ten-m

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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