Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro

Beatrix P. Rubin, Richard P Tucker, Marianne Brown-Luedi, Doris Martin, Ruth Chiquet-Ehrismann

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The transmembrane glycoprotein teneurin 2 is expressed by neurons in the developing avian thalamofugal visual system at periods that correspond with target recognition and synaptogenesis. Partial and full-length teneurin 2 constructs were expressed in cell lines in vitro. Expression of the cytoplasmic domain is required for the induction of filopodia, the transport of teneurin 2 into neurites and the co-localization of teneurin 2 with the cortical actin cytoskeleton. In addition, expression of the extracellular domain of teneurin 2 by HT1080 cells induced cell aggregation, and the extracellular domain of teneurin 2 became concentrated at sites of cell-cell contact in neuroblastoma cells. These observations indicate that the homophilic binding of teneurin 2 may play a role in the development of specific neuronal circuits in the developing visual system.

Original languageEnglish (US)
Pages (from-to)4697-4705
Number of pages9
JournalDevelopment
Volume129
Issue number20
StatePublished - Oct 2002
Externally publishedYes

Fingerprint

Cell Adhesion
Neurons
Cell Aggregation
Pseudopodia
Neurites
Neuroblastoma
Actin Cytoskeleton
Glycoproteins
Cell Line
In Vitro Techniques

Keywords

  • Chicken
  • DOC4
  • Neurestin
  • Odz
  • Ten-m
  • Ten
  • Ten

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro. / Rubin, Beatrix P.; Tucker, Richard P; Brown-Luedi, Marianne; Martin, Doris; Chiquet-Ehrismann, Ruth.

In: Development, Vol. 129, No. 20, 10.2002, p. 4697-4705.

Research output: Contribution to journalArticle

Rubin, BP, Tucker, RP, Brown-Luedi, M, Martin, D & Chiquet-Ehrismann, R 2002, 'Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro', Development, vol. 129, no. 20, pp. 4697-4705.
Rubin, Beatrix P. ; Tucker, Richard P ; Brown-Luedi, Marianne ; Martin, Doris ; Chiquet-Ehrismann, Ruth. / Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro. In: Development. 2002 ; Vol. 129, No. 20. pp. 4697-4705.
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