Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro

Beatrix P. Rubin, Richard P Tucker, Marianne Brown-Luedi, Doris Martin, Ruth Chiquet-Ehrismann

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The transmembrane glycoprotein teneurin 2 is expressed by neurons in the developing avian thalamofugal visual system at periods that correspond with target recognition and synaptogenesis. Partial and full-length teneurin 2 constructs were expressed in cell lines in vitro. Expression of the cytoplasmic domain is required for the induction of filopodia, the transport of teneurin 2 into neurites and the co-localization of teneurin 2 with the cortical actin cytoskeleton. In addition, expression of the extracellular domain of teneurin 2 by HT1080 cells induced cell aggregation, and the extracellular domain of teneurin 2 became concentrated at sites of cell-cell contact in neuroblastoma cells. These observations indicate that the homophilic binding of teneurin 2 may play a role in the development of specific neuronal circuits in the developing visual system.

Original languageEnglish (US)
Pages (from-to)4697-4705
Number of pages9
JournalDevelopment
Volume129
Issue number20
StatePublished - Oct 2002
Externally publishedYes

Keywords

  • Chicken
  • DOC4
  • Neurestin
  • Odz
  • Ten-m
  • Ten
  • Ten

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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