Tenascins in stem cell niches

Ruth Chiquet-Ehrismann, Gertraud Orend, Matthias Chiquet, Richard P Tucker, Kim S. Midwood

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalMatrix Biology
StatePublished - Jul 1 2014


  • Cancer
  • Development
  • Hematopoiesis
  • Inflammation
  • Stem cell niche
  • Tenascin

ASJC Scopus subject areas

  • Molecular Biology


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