Tenascins and their implications in diseases and tissue mechanics

F. Brellier, Richard P Tucker, R. Chiquet-Ehrismann

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Tenascins are glycoproteins found in the extracellular matrix (ECM) of many tissues. Their role is not only to support the tissue structurally but also to regulate the fate of the different cell types populating the ECM. For instance, tenascins are required when active tissue modeling during embryogenesis or re-modeling after injury occurs. Interestingly, the four members of the tenascin family, tenascin-C, -X, -R and -W, show different and often mutually exclusive expression patterns. As a consequence, these structurally related proteins display distinct functions and are associated with distinct pathologies. The present review aims at presenting the four members of the tenascin family with respect to their structure, expression patterns and implications in diseases and tissue mechanics.

Original languageEnglish (US)
Pages (from-to)511-519
Number of pages9
JournalScandinavian Journal of Medicine and Science in Sports
Volume19
Issue number4
DOIs
StatePublished - Aug 2009

Keywords

  • Asthma
  • Cancer
  • Ehlers Danlos
  • Inflammation
  • Tumor stroma

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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