Tenascins and the importance of adhesion modulation

Ruth Chiquet-Ehrismann, Richard P Tucker

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Tenascins are a family of extracellular matrix proteins that evolved in early chordates. There are four family members: tenascin-X, tenascin-R, tenascin-W, and tenascin-C. Tenascin-X associates with type I collagen, and its absence can cause Ehlers-Danlos Syndrome. In contrast, tenascin-R is concentrated in perineuronal nets. The expression of tenascin-C and tenascin-W is developmentally regulated, and both are expressed during disease (e.g., both are associated with cancer stroma and tumor blood vessels). In addition, tenascin- C is highly induced by infections and inflammation. Accordingly, the tenascin-C knockout mouse has a reduced inflammatory response. All tenascins have the potential to modify cell adhesion either directly or through interaction with fibronectin, and celltenascin interactions typically lead to increased cell motility. In the case of tenascin-C, there is a correlation between elevated expression and increased metastasis in several types of tumors.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalCold Spring Harbor perspectives in biology
Volume3
Issue number5
DOIs
StatePublished - May 2011

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Tenascin
Adhesion
Modulation
Tumors
Chordata
Vascular Tissue Neoplasms
Ehlers-Danlos Syndrome
Extracellular Matrix Proteins
Cell adhesion
Blood vessels
Collagen Type I
Fibronectins
Knockout Mice
Cell Adhesion
Cell Movement
Neoplasms
Neoplasm Metastasis
Inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tenascins and the importance of adhesion modulation. / Chiquet-Ehrismann, Ruth; Tucker, Richard P.

In: Cold Spring Harbor perspectives in biology, Vol. 3, No. 5, 05.2011, p. 1-19.

Research output: Contribution to journalArticle

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