Tenascin-C at a glance

Kim S. Midwood, Matthias Chiquet, Richard P Tucker, Gertraud Orend

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tenascin-C protein synthesis is tightly regulated, with widespread protein distribution in embryonic tissues, but restricted distribution of tenascin-C in adult tissues. Tenascin-C is also expressed de novo during wound healing or in pathological conditions, including chronic inflammation and cancer. First described as a modulator of cell adhesion, tenascin-C also directs a plethora of cell signaling and gene expression programs by shaping mechanical and biochemical cues within the cellular microenvironment. Exploitment of the pathological expression and function of tenascin-C is emerging as a promising strategy to develop new diagnostic, therapeutic and bioengineering tools. In this Cell Science at a Glance article and the accompanying poster we provide a succinct and comprehensive overview of the structural and functional features of tenascin-C and its potential roles in developing embryos and under pathological conditions.

Original languageEnglish (US)
Pages (from-to)4321-4327
Number of pages7
JournalJournal of Cell Science
Volume129
Issue number23
DOIs
StatePublished - 2016

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Tenascin
Cellular Microenvironment
Bioengineering
Posters
Proteins
Extracellular Matrix Proteins
Alternative Splicing
Cell Surface Receptors
Tissue Distribution
Phylogeny
Fibronectins
Cell Adhesion
Wound Healing
Cues
Vertebrates
Embryonic Structures
Inflammation
Phenotype
Gene Expression

Keywords

  • Cancer
  • Chronic inflammation
  • Extracellular matrix
  • Matricellular molecule
  • Tenascin-C
  • Tissue repair
  • TNC

ASJC Scopus subject areas

  • Cell Biology

Cite this

Midwood, K. S., Chiquet, M., Tucker, R. P., & Orend, G. (2016). Tenascin-C at a glance. Journal of Cell Science, 129(23), 4321-4327. https://doi.org/10.1242/jcs.190546

Tenascin-C at a glance. / Midwood, Kim S.; Chiquet, Matthias; Tucker, Richard P; Orend, Gertraud.

In: Journal of Cell Science, Vol. 129, No. 23, 2016, p. 4321-4327.

Research output: Contribution to journalArticle

Midwood, KS, Chiquet, M, Tucker, RP & Orend, G 2016, 'Tenascin-C at a glance', Journal of Cell Science, vol. 129, no. 23, pp. 4321-4327. https://doi.org/10.1242/jcs.190546
Midwood KS, Chiquet M, Tucker RP, Orend G. Tenascin-C at a glance. Journal of Cell Science. 2016;129(23):4321-4327. https://doi.org/10.1242/jcs.190546
Midwood, Kim S. ; Chiquet, Matthias ; Tucker, Richard P ; Orend, Gertraud. / Tenascin-C at a glance. In: Journal of Cell Science. 2016 ; Vol. 129, No. 23. pp. 4321-4327.
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