Temporally and Spatially Distinct Thirst Satiation Signals

Vineet Augustine, Haruka Ebisu, Yuan Zhao, Sangjun Lee, Brittany Ho, Grace O. Mizuno, Lin Tian, Yuki Oka

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

For thirsty animals, fluid intake provides both satiation and pleasure of drinking. How the brain processes these factors is currently unknown. Here, we identified neural circuits underlying thirst satiation and examined their contribution to reward signals. We show that thirst-driving neurons receive temporally distinct satiation signals by liquid-gulping-induced oropharyngeal stimuli and gut osmolality sensing. We demonstrate that individual thirst satiation signals are mediated by anatomically distinct inhibitory neural circuits in the lamina terminalis. Moreover, we used an ultrafast dopamine (DA) sensor to examine whether thirst satiation itself stimulates the reward-related circuits. Interestingly, spontaneous drinking behavior but not thirst drive reduction triggered DA release. Importantly, chemogenetic stimulation of thirst satiation neurons did not activate DA neurons under water-restricted conditions. Together, this study dissected the thirst satiation circuit, the activity of which is functionally separable from reward-related brain activity. The mammalian thirst circuit receives temporally distinct satiation signals by both liquid gulping action and gut osmolality sensing. These thirst satiation signals are functionally separable from the reward-related circuit activity.

Original languageEnglish (US)
Pages (from-to)242-249.e4
JournalNeuron
Volume103
Issue number2
DOIs
StatePublished - Jul 17 2019

Keywords

  • appetite
  • gut-brain axis
  • homeostasis
  • reward circuit
  • satiation
  • thirst

ASJC Scopus subject areas

  • Neuroscience(all)

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    Augustine, V., Ebisu, H., Zhao, Y., Lee, S., Ho, B., Mizuno, G. O., Tian, L., & Oka, Y. (2019). Temporally and Spatially Distinct Thirst Satiation Signals. Neuron, 103(2), 242-249.e4. https://doi.org/10.1016/j.neuron.2019.04.039