Abstract
Temporal lobe epilepsy (TLE) has long been the focus of both clinical and basic laboratory investigations. Most studies have approached this common and often medically refractory form of epilepsy as a unitary disorder. TLE has been identified as perhaps the prototypical 'acquired' epilepsy, thought to arise as a result of a brain injury or insult. However, recent studies suggest that TLE may include a number of distinct disorders, some of which arise because of genetic mutations in genes that normally control patterns of brain development and/or excitability. Animal models can help to explore these possibilities. Two specific mouse models - the Kv1.1 knockout mouse and the p35 knockout mouse - show typical TLE-like seizure phenotypes and present with histopathological features also seen in human TLE. They arise, however, from very different processes; seizures in Kv1.1-/- mice reflect a 'channelopathy'-like disorder, while seizures in p35-/- mice arise from a disruption of normal brain development.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Basic Epilepsy Research |
| Publisher | Elsevier Inc. |
| Pages | 1361-1365 |
| Number of pages | 5 |
| ISBN (Print) | 9780123739612 |
| DOIs | |
| State | Published - Jan 1 2009 |
Fingerprint
Keywords
- 1
- Acquired epilepsy
- Granule cell dispersion
- Hippocampus
- Kv1
- LGI1
- P35
- Reelin
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Medicine(all)
- Neuroscience(all)
Cite this
Temporal Lobe Epilepsy : Genetic Determinants of Temporal Lobe Epilepsy. / Schwartzkroin, Philip A; Wenzel, H. Jurgen.
Encyclopedia of Basic Epilepsy Research. Elsevier Inc., 2009. p. 1361-1365.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Temporal Lobe Epilepsy
T2 - Genetic Determinants of Temporal Lobe Epilepsy
AU - Schwartzkroin, Philip A
AU - Wenzel, H. Jurgen
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Temporal lobe epilepsy (TLE) has long been the focus of both clinical and basic laboratory investigations. Most studies have approached this common and often medically refractory form of epilepsy as a unitary disorder. TLE has been identified as perhaps the prototypical 'acquired' epilepsy, thought to arise as a result of a brain injury or insult. However, recent studies suggest that TLE may include a number of distinct disorders, some of which arise because of genetic mutations in genes that normally control patterns of brain development and/or excitability. Animal models can help to explore these possibilities. Two specific mouse models - the Kv1.1 knockout mouse and the p35 knockout mouse - show typical TLE-like seizure phenotypes and present with histopathological features also seen in human TLE. They arise, however, from very different processes; seizures in Kv1.1-/- mice reflect a 'channelopathy'-like disorder, while seizures in p35-/- mice arise from a disruption of normal brain development.
AB - Temporal lobe epilepsy (TLE) has long been the focus of both clinical and basic laboratory investigations. Most studies have approached this common and often medically refractory form of epilepsy as a unitary disorder. TLE has been identified as perhaps the prototypical 'acquired' epilepsy, thought to arise as a result of a brain injury or insult. However, recent studies suggest that TLE may include a number of distinct disorders, some of which arise because of genetic mutations in genes that normally control patterns of brain development and/or excitability. Animal models can help to explore these possibilities. Two specific mouse models - the Kv1.1 knockout mouse and the p35 knockout mouse - show typical TLE-like seizure phenotypes and present with histopathological features also seen in human TLE. They arise, however, from very different processes; seizures in Kv1.1-/- mice reflect a 'channelopathy'-like disorder, while seizures in p35-/- mice arise from a disruption of normal brain development.
KW - 1
KW - Acquired epilepsy
KW - Granule cell dispersion
KW - Hippocampus
KW - Kv1
KW - LGI1
KW - P35
KW - Reelin
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=85069291570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069291570&partnerID=8YFLogxK
U2 - 10.1016/B978-012373961-2.00370-2
DO - 10.1016/B978-012373961-2.00370-2
M3 - Chapter
AN - SCOPUS:85069291570
SN - 9780123739612
SP - 1361
EP - 1365
BT - Encyclopedia of Basic Epilepsy Research
PB - Elsevier Inc.
ER -