Temporal effects of plasmapheresis on serum proteins in horses.

K G Magdesian, D. Brook, S. J. Wickler

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The temporal response of blood and serum proteins to chronic plasmapheresis was determined in 8 horses used in a commercial antibody enterprise. Plasmapheresis of between 4 and 11 L induced significant decreases in total protein, albumin, and IgG values. With the exception of a high hematocrit value for the first postplasmapheresis blood sample, there were no changes in erythrocyte or leukocyte measurements, and no changes in the proportions of serum protein in an electrophoretic profile. Regression equations generated for recovery of proteins after plasmapheresis indicated a return to preplasmapheresis values of total protein and albumin at approximately 1 month. Complications of repeated plasmapheresis were not detected when plasma extractions were done between 7 and 19 times at 30-day intervals.

Original languageEnglish (US)
Pages (from-to)1149-1153
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume53
Issue number7
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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